Eight-Gene Blood Test Shows Striking Accuracy in Detecting Heart Attacks
Researchers used nested machine learning on public blood transcriptome data to derive an eight-gene index that diagnoses acute myocardial infarction ...
Tag: inflammasome
Leftover Roots of a Korean Medicinal Herb Quiet a Brain Inflammation Trigger
Residue extracts of Angelica gigas retained decursin and decursinol angelate, which bound NLRP3 and dampened microglial inflammasome activation in cells ...
When Mitochondria Fail, Inflammatory Cell Death Follows in Brain and Spinal Cord Injury
A new review links mitochondrial failure to the inflammatory hybrid cell death program PANoptosis across stroke, hemorrhage, traumatic brain injury, ...
Inflammasome Biomarkers Could Predict Which Wounds Heal and Which Turn Chronic
A new review argues that inflammasome-derived molecular biomarkers could predict wound outcomes, distinguish healing from chronic inflammation, and guide precision ...
Trojan Horse Inhibitors Slip Through Gasdermin Pores to Shut Down Pyroptosis
New research shows that gasdermin D pores formed during pyroptosis can admit selectively designed caspase inhibitors, allowing the inflammatory cell ...
Immune Enzyme PTPN2 Emerges as Master Switch in Sepsis Inflammation
McGill University researchers have identified the enzyme PTPN2 as a key regulator of non-canonical inflammasome activation, revealing how it shapes ...
Overactive Inflammasome in Artery Muscle Cells Drives Dangerous Vessel Thickening in Mice
A new mouse study shows that hyperactive NLRP3 inflammasome signaling within vascular smooth muscle cells drives inflammation, pyroptosis, lipid accumulation, ...
AI-Designed Gasdermins Programmed to Destroy Virus-Infected Cells
A Cell Research article examines how artificial intelligence-guided engineering of gasdermin pore-forming proteins could be harnessed to selectively eliminate virus-infected ...
Cryo-EM Reveals How ATP Switches Off the Human NLRP6 Inflammasome
Cryo-EM structures of human NLRP6 in ATP-bound and unbound conformations reveal how ATP serves as an endogenous inhibitor of inflammasome ...
Innate Immune Sensors in Focus: Structural Insights into Inflammasomes and PANoptosomes Open New Therapeutic Avenues
A Cell Research review synthesizes structural and mechanistic insights into inflammasomes and PANoptosomes, revealing how innate immune sensors assemble inflammatory ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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