Fibroblasts Recruit Antitumor B Cells in Liver Cancer, Study Finds
Spatial transcriptomic mapping of liver tumors has revealed that CCL19-producing fibroblasts recruit CXCR3-positive B cells to form an antitumor axis ...
Tag: Immunotherapy
Lab-Grown Tumor Organoids Illuminate How Cancers Evade, Tolerate, and Resist Treatment
A new review in Molecular Cancer positions patient-derived organoids as living systems for mapping how cancers tolerate, persist through, and ...
Silenced APP Protein Reveals Why Pediatric Brain Tumors Hide From the Immune System
An integrated multi-omics study shows that mesenchymal-like tumor cells drive myeloid recruitment in pediatric high-grade glioma and that reduced amyloid ...
Gut and Oral Microbes Emerge as Hidden Players in Brain Tumour Biology
A new review in Nature Reviews Neurology synthesizes evidence that gut and oral microbes, and even bacteria residing within brain ...
Rare Bladder Metastasis From Kidney Cancer Emerges After Targeted Therapy Fails
Clinicians in China report an extraordinarily rare case of clear cell kidney cancer spreading to the bladder without symptoms after ...
CRISPR Screens Reveal DNMT3A’s Dual Role in Tumor Immune Evasion
In vivo CRISPR screens reveal that the epigenetic enzyme DNMT3A can both preserve and suppress tumor immune visibility, reshaping how ...
Why Chronic Hepatitis B Still Defies a Functional Cure: New Review Maps the Immunological Barriers
A new review in Virology Journal explains how cccDNA persistence, viral genome integration and multi-level immune exhaustion keep functional cure ...
Interleukin-2 emerges as both engine and saboteur in tumor-infiltrating lymphocyte therapy
A new review details how interleukin-2 both powers and undermines tumor-infiltrating lymphocyte therapy, and how engineered alternatives may finally break ...
Severe MOGAD in Children: ICU Study Reveals Seizures and Brain Pressure Risks
A large single-center case series finds that critically ill children with MOGAD frequently suffer seizures, status epilepticus, and elevated intracranial ...
Personalized Neoantigen Vaccine Turns a Patient’s Immune System Into a TCR Discovery Engine
A personalized dendritic cell neoantigen vaccine given to an ovarian cancer patient enabled Swiss researchers to track expanding T-cell clonotypes ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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