RNA Modification and Cell Death Genes Point to New Prognostic Tool for Ovarian Cancer
Researchers built a machine learning gene signature combining RNA modification and programmed cell death biology that predicts survival and immunotherapy ...
Tag: Immunotherapy
Immune Checkpoint TREM2 Emerges as a Switch to Supercharge CAR Macrophages Against Breast Cancer
New research shows that blocking the TREM2 receptor reprograms HER2-targeted CAR macrophages from suppressive to inflammatory, tumor-engulfing cells in breast ...
Silent Receptor Boost: Non-Signaling CARs Supercharge T-Cells Against Head and Neck Cancer
Researchers in Düsseldorf report that co-expressing a non-signaling EGFR-binding CAR alongside EGFRvIII-specific CAR T-cells enhances killing of head and neck ...
Radiotherapy Backfires: PD-1-Positive Monocytes Emerge as Hidden Drivers of Treatment Resistance
New research reveals that radiotherapy induces PD-1 expression on tumor-associated monocytes through an adenosine-driven signaling pathway, creating an immunosuppressive cell ...
Engineered Immune Cells Push Melanoma Therapy Into a New Era
A new review details how tumor-infiltrating lymphocyte, CAR-T, and TCR-engineered cell therapies are transforming melanoma treatment and the engineering breakthroughs ...
Immune Checkpoint VISTA Doubles as a Growth Engine Inside Mesothelioma Cells
New research shows the immune checkpoint molecule VISTA also drives proliferation within mesothelioma cells through RIPK1-associated and AKT-dependent signalling, making ...
From Bench to Bedside: New Tools Push Veterinary Oral Cancer Toward Targeted Therapy
New spatial transcriptomics, patient-derived models, and comparative clinical trials of trametinib and a STAT3 decoy are transforming the treatment of ...
Sunlight, Seasons and Survival: Vitamin D Fails to Explain Timing Effects in Immunotherapy
A large UK pan-cancer study finds no consistent link between the season of checkpoint inhibitor initiation and overall survival, despite ...
Immune Cell Signal Reveals How Triple Therapy Reshapes Liver Tumors
New research shows that triple therapy for unresectable liver cancer is associated with denser, more mature intratumoral tertiary lymphoid structures ...
Melanoma survivors face a care gap: major review maps what works and what is missing
A new scoping review of 21 studies identifies seven melanoma survivorship care programs worldwide but finds that none covers all ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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