Fluid Once Discarded After Cancer Surgery Reveals a Hidden Immune Cell That May Shield Tumors
A Mass General Brigham study of malignant ascites has identified rare RORC-expressing dendritic cells that may promote immune tolerance in ...
Tag: Immunotherapy
Blood Test Clue: Immune Cells That Betray Early Lung Cancer Before It Strikes
Researchers have discovered a clonally coordinated network of suppressive regulatory T cells that spans the blood, lymph nodes and airways ...
How Pseudomonas aeruginosa Hijacks Protective T Cells to Fuel Cystic Fibrosis Lung Damage
New research shows Pseudomonas aeruginosa reprograms protective Th17 cells into pathogenic interferon-gamma-producing effectors that directly damage the cystic fibrosis lung ...
Ultrasound-Driven Bioactive Microrobots Deliver a Multi-Weapon Strike Against Bladder Cancer
An engineered ultrasound-responsive microrobot combining collagen-degrading bacteria, nanoparticles, and a targeted drug achieved strong tumor inhibition and immune activation in ...
Experimental Drug Tolinapant Boosts Immunotherapy Response in Advanced Solid Tumors
A phase I trial found that the IAP antagonist tolinapant combined with pembrolizumab was well tolerated and produced a 33 ...
Hidden Immune Saboteurs: Scientists Map the Cells That Shield Colorectal Tumors
By combining spatial and single-cell transcriptomics, researchers have mapped previously unknown immunosuppressive niches in colorectal cancer, including SPP1-positive macrophage rings ...
NIH Backs $13.1 Million Effort to Attack Breast Cancer with Engineered Salmonella
A five-year, $13.1 million NIH grant will fund engineered, nontoxic Salmonella designed to deliver radiopharmaceutical therapy, viral payloads, and immune-targeting ...
Orphan Nuclear Receptor Ligands Trigger Ferroptosis and Reshape Immunity in Colon Cancer
New research shows that synthetic ligands for the orphan nuclear receptors NR4A1 and NR4A2 induce iron-dependent cell death in colon ...
LSU Health New Orleans Hires Star Radiation Oncologist to Build First Academic Department
LSU Health New Orleans has recruited radiation oncologist Dr. Puneeth Iyengar from Memorial Sloan Kettering to establish its first academic ...
Early Symptoms May Predict Survival in Advanced Kidney Cancer, CheckMate 9ER Analysis Shows
A post hoc analysis of the CheckMate 9ER trial links early worsening of bone pain and sleep quality to higher ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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