Radiation or Surgery After Dual Immunotherapy Fails to Extend Survival in Metastatic Lung Cancer
The Phase III LONESTAR trial found that adding radiation or surgery after nivolumab plus ipilimumab did not improve survival in ...
Tag: Immunotherapy
Ibrutinib Triggers Matriptase to Preserve CD19 and Block Antigen Escape in B-Cell Malignancy
New research shows that the BTK inhibitor ibrutinib activates the protease matriptase in malignant B cells, preserving surface CD19 and ...
T Cells Can Wipe Out Tumors Without Ever Recognizing Them
New research shows that activating bystander T cells inside tumors triggers antigen-independent tumor killing through cytokines, nitric oxide and innate ...
Neutrophils in Cancer: The Immune Cells That Turn Traitors and Healers
A comprehensive new review reveals how neutrophils, the immune system's most abundant white blood cells, are co-opted by tumors to ...
Radium-223 Therapy Lowers PD-L1 in Prostate Cancer Bone Metastases, PET Study Shows
A prospective imaging study shows that radium-223 significantly reduces PD-L1 expression and depletes immune cells in prostate cancer bone metastases, ...
Fatigue During Immunotherapy Does Not Track With Fitness, Study Finds
A German study finds that cancer patients on immune checkpoint inhibitors report far more chronic fatigue and lower fitness than ...
Feedback Loops, Not Pipelines: The Data-Centric Fix for Failing Immunotherapy Development
Researchers propose reframing drug development as an iterative, data-centric learning system in which single-cell readouts from human immunotherapy responses continuously ...
Radiotherapy Reimagined as an Immune Weapon Against Pancreatic Cancer
A new perspective argues that radiation must be redesigned as an immunological platform to finally unlock the potential of combined ...
PET Imaging Reveals Whether Immunotherapy Drugs Actually Reach Their Tumour Targets
Researchers are using PD-L1-targeted PET/CT imaging to directly visualise whether the immunotherapy drug atezolizumab saturates its target in tumours, offering ...
METTL3 Emerges as a Molecular Hub Driving Tumor Immune Escape
A new review in the Journal of Translational Medicine details how the RNA methyltransferase METTL3 drives tumor immune escape through ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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