PD-L1 Levels Fail to Predict ALK Inhibitor Benefit in Lung Cancer Cohort
A 129-patient Japanese multicenter study found that tumor PD-L1 expression did not predict the effectiveness of ALK inhibitor therapy in ...
Tag: Immunotherapy
Liver Injury Affects One in Eight Patients on Immune Checkpoint Inhibitors in Real-World Study
A retrospective study of 682 patients in Tianjin found 12.17 percent developed liver injury on immune checkpoint inhibitor therapy, with ...
JAK/STAT Signalling Emerges as Central Player in Post-COVID Autoimmune Syndromes
A new review highlights the JAK/STAT signalling pathway as a potential link between SARS-CoV-2 infection, post-COVID autoimmune phenomena and the ...
Gladstone Scientists Melanie Ott and Alex Marson Join National Academy of Medicine
Gladstone Institutes physician-scientists Melanie Ott and Alex Marson have been elected to the National Academy of Medicine in recognition of ...
Tarlatamab plus durvalumab extends survival in first-line maintenance for extensive-stage small cell lung cancer
Phase 3 DeLLphi-305 results show that adding tarlatamab to durvalumab as first-line maintenance therapy extended median overall survival by more ...
Natural Killer Cells in Liver Metastasis Prove Far More Than Simple Killers
A new review argues that natural killer cells in colorectal cancer liver metastasis form a heterogeneous, microenvironment-shaped spectrum of states ...
International tumor board weighs personalized options for colon cancer with no measurable disease
A case report in Oncotarget describes how an international molecular tumor board weighed treatment options for a 52-year-old woman with ...
RNF152 Tags PD-L1 for Destruction and Curbs Immune Evasion in Kidney Cancer
A study in Medical Oncology reports that the E3 ubiquitin ligase RNF152 is low in clear cell renal cell carcinoma, ...
Oral bacterium’s metabolites reshape colorectal cancer and immunotherapy outcomes
A new review details how metabolites produced by Fusobacterium nucleatum drive periodontal inflammation, reprogram colorectal tumor metabolism and immunity, and ...
Macrophages, Fibroblasts and Cancer Cells Conspire to Switch On a Tumor-Fueling Protein in Pancreatic Cancer
A new study shows that cooperative signals from macrophages, stellate cells and cancer cells switch on the tumor-promoting protein CHI3L1 ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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