T cells in AML are not uniformly dysfunctional, researchers argue in new analysis
A BMC Medicine debate article argues that T cells in acute myeloid leukemia are not uniformly dysfunctional and that assessing ...
Tag: Immunotherapy
Massive Trial Network Crowns Cisplatin King of Head and Neck Cancer Radiotherapy Boosters
A network meta-analysis of 44 randomised trials ranks 24 radiosensitising strategies for locally advanced head and neck cancer, finding cisplatin ...
Engineered T-BET Pushes Lab-Grown NK Cells Toward Inflammation, Not Full Maturity
Forcing T-BET expression in iPSC-derived NK cells boosted IFN gamma and inflammatory chemokines but left cytotoxic function and terminal maturation ...
Hong Kong Team Makes CAR-T Therapy for Children With Leukaemia in Just 14 Days
A Hong Kong phase II trial of six children found that locally manufactured point-of-care CD19 CAR-T cells, produced in 14 ...
Rare MSH2 Variant Linked to Three Cancers in One Lynch Syndrome Patient
A Frontiers in Oncology case report documents a 62-year-old woman carrying the known pathogenic MSH2 p.A230Lfs*16 germline variant who developed ...
New framework proposes how to pick safer targets for senolytic immunotherapy
A proposed four-criteria framework for selecting senescence-associated antigens finds that neither uPAR nor GPNMB currently meets all requirements.
Lung Cancer Rewrites Its Identity: Rare Squamous Transformation Tracked by Genomic Sequencing
A case report documents an EGFR-mutant lung adenocarcinoma transforming into squamous cell carcinoma after multiple therapies, with newly detected SMAD4 ...
Extracellular vesicles emerge as dual players in tumor immunity and drug resistance
A new editorial argues that extracellular vesicles both drive tumor adaptation and drug resistance and offer promising platforms for antitumor ...
Epigenetic Aging Inside Tumors May Shape Immunotherapy Response Beyond Chronological Age
A new review synthesizes evidence that DNA methylation, chromatin and non-coding RNA changes reshape immune and stromal cells in the ...
Pembrolizumab Brings Heavy Toxicity Burden for Older Breast Cancer Patients in Real-World Care
A real-world cohort study of 136 patients aged 65 and older found high rates of hospitalization and immune-related toxicity with ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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