CD58 Emerges as a Central Player in How Tumors Evade Immune Attack and Resist Therapy
A new review in Molecular Cancer details how loss of the immune synapse molecule CD58 drives tumor immune evasion and ...
Tag: Immunotherapy Resistance
Lab-Grown Tumor Organoids Illuminate How Cancers Evade, Tolerate, and Resist Treatment
A new review in Molecular Cancer positions patient-derived organoids as living systems for mapping how cancers tolerate, persist through, and ...
CYP2S1 enzyme linked to immunotherapy resistance in esophageal cancer
New research identifies the enzyme CYP2S1 as a driver of immunosuppressive cell recruitment and poor chemoimmunotherapy response in esophageal squamous ...
Tumour Matrisome Emerges as a Rich Source of Cancer Biomarkers and Drug Targets
A new review in Nature Reviews Clinical Oncology details how the tumour extracellular matrix, or matrisome, drives cancer progression and ...
Dual T-Cell Activator Breathes New Life Into Checkpoint Therapy for Resistant Cancers
A selective dual T-cell activator directed at the TCR beta chain revives exhausted antitumor T cells and sensitizes checkpoint-resistant cancers ...
Hidden Protein Signals Decide Why Immunotherapy Fails in Gut Cancers
A new review maps how secreted protein circuits in gastrointestinal tumours govern immune recruitment, suppression and response to checkpoint immunotherapy.
Tumor Vesicles Loaded with SPP1 Rewire Fibroblasts to Shield Lung Cancer from Immunity
New research shows that lung adenocarcinoma cells package the protein SPP1 into extracellular vesicles to reprogram fibroblasts into an MMP11-positive ...
METTL3 Emerges as a Molecular Hub Driving Tumor Immune Escape
A new review in the Journal of Translational Medicine details how the RNA methyltransferase METTL3 drives tumor immune escape through ...
Why Blocking One Immune Enzyme Fails: Cells Reroute Tryptophan Metabolism
A new review explains why IDO1 inhibitors often fail, revealing that tumors and tissues compensate by rerouting tryptophan metabolism through ...
Common Painkillers Show New Promise in Cancer Prevention and Treatment
A new review synthesizes decades of evidence showing that selective COX-2 inhibitors can suppress tumor initiation, growth and immunotherapy resistance ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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