How Microbial Imbalances Shape Lung Cancer Growth and Treatment Failure
A new review details how microbial imbalances in the gut, airways, mouth, and tumors drive lung cancer progression and undermine ...
Tag: Immunotherapy Resistance
Silencing NOTCH1 Makes Leukemia Cells Vulnerable to CD19 CAR-T Attack
New research shows that blocking the NOTCH1 signaling pathway prevents leukemia cells from degrading the CD19 antigen, making them far ...
RNA Tagging Enzyme METTL16 Fuels Colorectal Cancer by Hijacking Amino Acid Metabolism and Silencing Immune Cells
New research shows that the RNA methyltransferase METTL16 drives colorectal cancer growth and immune evasion by stabilizing BCAT1 mRNA and ...
AI Knockout Screen Reveals GSTP1 as a Driver of Lung Cancer Immunotherapy Resistance
A transformer-based in-silico gene knockout screen across 109 cell types has identified GSTP1 as a key driver of immunotherapy resistance ...
Oral Wnt-blocking pill plus lenvatinib shows promise in endometrial cancer after immunotherapy fails
A phase 1b/2 trial found that the oral CBP–β-catenin inhibitor E7386 combined with lenvatinib produced durable responses in advanced endometrial ...
Ancient Herbal Formulas May Hold the Key to Unlocking Immunotherapy for Hard-to-Treat Colorectal Cancer
A new review proposes that standardized Traditional Chinese Medicine formulas could re-engineer the gut microbiome, myeloid cells, and tumor cell ...
Single-Cell Map Reveals Vascular Barrier That Predicts BCG Failure in Bladder Cancer
A stage-spanning single-cell atlas of bladder cancer identifies a CXCR4-positive vascular-immune barrier at the T1 stage that excludes T cells ...
Staphylococcal Protein Reprograms Liver Tumor Macrophages to Boost Immunotherapy
A bacterial protein called LukS-PV reprograms immunosuppressive macrophages in liver cancer by targeting the human C5aR1 receptor, restoring CD8-positive T-cell ...
Melanoma’s Genetic Blueprint Builds Immune-Proof Tumor Neighborhoods, Study Finds
Researchers at NYU Grossman School of Medicine show that loss of the NF1 tumor suppressor reorganizes melanoma tumors into immunosuppressive ...
New Immune Checkpoint Discovery Explains Why Gastric Cancers Ignore PD-1 Drugs
Researchers created a mouse model of refractory gastric cancer and discovered that the YAP-driven BST2 protein reprograms neutrophils and Kupffer ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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