Gene brake ZMYND8 drives T-cell exhaustion and blocking it may strengthen immunotherapy
St. Jude scientists found that deleting the gene ZMYND8 relieves CD8-positive T-cell exhaustion and synergizes with immunotherapy to improve anti-tumor ...
Tag: Immunotherapy Resistance
Persister cells hiding in minimal residual disease drive cancer relapse
A new review outlines how drug-tolerant persister cells hidden within minimal residual disease drive cancer relapse and how pathway inhibitors, ...
SRPX2 Emerges as a Master Switch Behind Colorectal Cancer Spread and Immune Evasion
New research identifies the secreted protein SRPX2 as a molecular switch that stabilizes the TGF-beta receptor to drive metastasis and ...
A Hidden RNA Splice Variant May Predict Relapse After CD19 CAR-T Therapy
Danish researchers report that low-level skipping of CD19 exon 2, detectable in pre-treatment RNA-sequencing data, correlates with relapse after anti-CD19 ...
AI Model Links Calcium Pump Gene ATP2A2 to Immune Evasion in Lung Cancer
A machine learning analysis of inflammation and metabolism genes across seven lung adenocarcinoma cohorts identifies the calcium pump gene ATP2A2 ...
Why the Immune System Fails Some Bladder Cancers and How Scientists Are Fighting Back
A new review explains why BCG immunotherapy fails in some bladder cancer patients and outlines emerging combination strategies designed to ...
How Low Oxygen Helps Neuroblastoma Turn Killer T Cells Off
New research shows that oxygen-starved neuroblastoma cells stabilize HIF-1α, which directly activates PD-L1 transcription and drives CD8+ T-cell dysfunction, a ...
New Cancer Framework Ties Epigenetics, DNA Repair and Immunity Into One Immunogenicity Score
A new multi-omics framework proposes that tumor immunogenicity emerges only when epigenetic permissiveness, DNA damage response configuration and immune activation ...
Immune Evasion in Metastatic Colorectal Cancer May Start Outside the Tumor Cell, Study Finds
An international research team reports that the sphingosine-1-phosphate signaling long thought to operate inside colorectal cancer cells instead builds an ...
Single-cell map shows how pancreatic cancer clones evolve to outsmart treatment
A single-cell analysis of nearly half a million cells from pancreatic tumors reveals how evolving clones reshape their DNA to ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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