Lactate Fuels a Hidden Molecular Chain That Helps Liver Cancer Evade Immunity
A new study reveals how lactate-driven lactylation of histone and non-histone proteins in liver cancer activates a METTL3-FDFT1 cholesterol pathway ...
Tag: immunosuppression
Stressed immune cells may help liver cancer invade blood vessels, study finds
Researchers have identified a stress-responsive subset of MAIT cells that promotes an immunosuppressive peritumoral environment and microvascular invasion in hepatocellular ...
RGS Proteins Emerge as Hidden Architects of the Tumor Microenvironment
A new review in the Journal of Translational Medicine details how RGS proteins, the off switches of GPCR signaling, reshape ...
Why EGFR Drugs Fail in Glioblastoma: A STAT3 Escape Route Takes Center Stage
A new review argues that glioblastoma evades EGFR-targeted therapies through compensatory STAT3 activation, positioning the EGFR–STAT3 axis as an adaptive ...
Immune Receptor LAIR1 Blocks Cancer Cell Engulfment in Brain Tumours
New research in the British Journal of Cancer shows that the collagen-binding receptor LAIR1 disables the phagocytic machinery of glioma-associated ...
Thymectomy Works Just as Well in Older Myasthenia Gravis Patients, Study Finds
A Cleveland Clinic study of 79 patients finds that thymectomy delivers comparable safety and efficacy in older and younger patients ...
Belly Fat, Not BMI, May Raise Lung Cancer Risk by Silencing Airway Immunity
A study of more than 1,100 high-risk individuals links abdominal fat measured by CT scans to lung cancer and shows ...
Pregnancy Drug Patterns in Myasthenia Gravis Reveal Four Distinct Patient Journeys
A landmark Nordic register study of 339 pregnancies has identified four distinct medication use trajectories in women with myasthenia gravis, ...
Liver Metastases Shorten Survival on Chemotherapy but Not Immunotherapy in Pancreatic Cancer
A pooled analysis of four clinical trials finds that liver metastases are a strong negative prognostic factor for chemotherapy-treated pancreatic ...
Why the Mouth Matters: Dentists Join the CAR-T Therapy Team
Hematologists argue that preventive dental care and oral health assessment should become a standard part of the CAR-T cell therapy ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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