Three Promising Hodgkin Lymphoma Biomarkers Fail Prognostic Test in Major Trial
A rigorous analysis of the EORTC-GELA H9 randomised trial finds that the tissue biomarkers c-MET, HLA class II, and CD68 ...
Tag: immunohistochemistry
Sticky Protein MUC5AC Emerges as Powerful Tissue Marker for Pancreatic Cancer and Precursors
A meta-analysis of 55 studies shows the mucus protein MUC5AC distinguishes pancreatic cancer and precancerous lesions from healthy and benign ...
New Antibody-Drug Conjugate SCR-A008 Shows Powerful Tumor Suppression in Gastric Cancer Models
A novel CDH17-targeted antibody-drug conjugate called SCR-A008 achieved sustained tumor inhibition in gastric cancer PDX models, with a paclitaxel combination ...
AI Reveals Why Pathologists Disagree on HER2 Scoring in Breast Cancer
A Brazilian study found that an AI model's measure of HER2 staining heterogeneity within breast cancer samples predicts where pathologists ...
Beyond target expression: a modular framework to predict who benefits from antibody–drug conjugates
A Nature Reviews Clinical Oncology Review proposes a modular biomarker framework that moves ADC patient selection beyond semi-quantitative immunohistochemistry by ...
Breast Cancer Cells Recruit Immune Allies Through TNFAIP3 to Drive Metastasis
A new study shows that high TNFAIP3 expression in breast cancer cells drives CCL2/CCR2-mediated M2-like macrophage polarization and that combining ...
Immunophenotypic Markers Reveal Poor Survival in Ghanaian Children With Non-Hodgkin Lymphoma
A Ghanaian study of 38 children with non-Hodgkin lymphoma found that BCL-2 expression and tumor spread significantly predicted survival, with ...
FGFR3 Protein Overexpression Predicts Bladder Cancer Recurrence, Study Finds
A Barcelona study of 87 patients shows that FGFR3 protein overexpression independently predicts recurrence in high-grade T1 bladder cancer, while ...
Hormone-Driven Tumors Show Stronger Apelin Staining, First Study of Its Kind Finds
A first-of-its-kind immunohistochemical study reports that cortisol-producing adrenal adenomas display significantly stronger apelin staining than normal adrenal cortex, while VEGF ...
Rare Giant Lung Tumour With Suspected Liver Spread Challenges Diagnosis and Treatment
A case report describes a 57-year-old woman with a giant intrapulmonary solitary fibrous tumour exceeding 16 centimetres, complicated by suspected ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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