Fibroblast protein APOL4 flags platinum-sensitive ovarian tumors
Researchers report that stromal APOL4 marks a distinct cancer-associated fibroblast state whose loss confers carboplatin resistance in ovarian cancer co-cultures ...
Tag: immune infiltration
TAM receptors and STAT–SOCS signaling shape the immune landscape of thymic epithelial tumors
A new integrative analysis links TAM receptor and STAT–SOCS signaling to immune infiltration patterns in thymic epithelial tumors.
LIFR expression linked to stomach cancer prognosis in TCGA analysis
A bioinformatics study of stomach adenocarcinoma found that low LIFR expression within tumors was associated with a more favorable prognosis, ...
Gene Signatures Linked to Resistance and Response to PD-1 Blockade in Skin Cancer
Pre-treatment gene signatures combining immune activity and tumor-intrinsic markers such as SLC7A5 and SOX2 are associated with response and resistance ...
Long non-coding RNA TMPO-AS1 flags poor outcomes in lung adenocarcinoma
A multi-database bioinformatics study identifies the long non-coding RNA TMPO-AS1 as overexpressed in lung adenocarcinoma and linked to poor survival ...
Gut Microbe and Gene Candidates Nominated for Inflammatory Myopathies
A multi-omics study computationally nominates the gut microbe Lachnoclostridium and the gene ENO1 as candidates in inflammatory myopathies, with cell ...
BUB1 kinase inhibition slows endometrial cancer growth in lab study
A multi-omics and in vitro study finds BUB1 overexpressed in endometrial carcinoma, linked to poor survival, and suppressible by the ...
Two Gene Biomarkers Linked to Sperm Production Failure in Infertility Study
An integrative analysis of human NOA transcriptomic data and a Utf1 conditional knockout mouse model identifies ACTRT2 and AKAP4 as ...
Chlorpyrifos Exposure Linked to Autism-Associated Genes in Computational Study
A computational study identified 206 shared genes and an exploratory four-gene signature linking chlorpyrifos targets to autism-associated pathways.
Low CEBPD Expression Tied to Poor Breast Cancer Survival, Study Finds
Researchers report that the adipogenesis-related gene CEBPD is downregulated in breast tumors, serves as an independent prognostic indicator of survival, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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