Ribosomal RNA Tag and a Detox Enzyme Form a Deadly Cancer Survival Circuit
A new review describes how the RNA methyltransferase METTL5 and the detox enzyme MGST1 form a signaling axis that helps ...
Tag: immune evasion
Immune-cell switch flips the metabolic war between tumors and T cells in immunotherapy-resistant cancers
A new study shows that activating the lipid sensor PPARĪ“ in immune cells rather than cancer cells flips the metabolic ...
KRAS-mutant tumors flood themselves with adenosine to blind immune cells
Researchers report that oncogenic KRAS reprograms adenosine metabolism through NT5E upregulation and ADA suppression, creating an immunosuppressive tumor microenvironment that ...
Chromatin Architect Satb1 Reveals a Switch That Disarms Tumor-Protective Immune Cells
New research shows the chromatin organizer Satb1 enables regulatory T cells to promote tumor growth while remaining dispensable for preventing ...
Single-cell atlas reveals how hidden clones drive pancreatic cancer’s deadly evolution
A landmark single-cell and spatial transcriptomics study of 62 pancreatic tumors shows that genetically distinct clones within each cancer drive ...
Hidden Ubiquitin Switch That Lets Brain Tumors Evade Immune Attack Is Revealed
New research reveals that the ubiquitin ligase BTRC destroys the RNA-binding protein hnRNPC, whose stabilization of PSD4 mRNA boosts PD-L1 ...
Deadly Fungus Morphs Into Tiny Titanide Cells Under Pressure From the Host
New research in PLOS Biology defines the titanide, a tiny stress-resistant cell type that Cryptococcus neoformans generates from typical yeast ...
Severe Hand, Foot and Mouth Disease Outbreak in Vietnam Traced to a Single Introduction of Enterovirus A71 Subgenogroup B5
A 2023 severe hand, foot and mouth disease outbreak in Vietnam was caused by a single introduction of enterovirus A71 ...
Collagen Clue: How COL6A1 May Drive Bile Duct Cancer’s Deadly Spread
A new review in Cancer Reports proposes that the extracellular matrix protein COL6A1, overexpressed in the fibrotic stroma of cholangiocarcinoma, ...
Tousled-Like Kinases TLK1 and TLK2 Emerge as Pan-Cancer Drivers of Genomic Instability and Immune Evasion
A pan-cancer analysis of 33 tumor types reveals that the DNA-repair kinases TLK1 and TLK2 drive genomic instability and shape ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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