Silencing PD-L1 Reveals a Hidden Phosphatase Axis That May Drive Gastric Cancer Survival
New research shows that silencing the PD-L1 gene in gastric cancer cells reshapes the expression of MAPK-regulating DUSP phosphatases, revealing ...
Tag: immune checkpoint
AI and Data Mining Take Center Stage in New Wave of Drug Discovery Research
The latest volume of SLAS Discovery showcases how artificial intelligence, deep learning and data-mining strategies are accelerating drug discovery across ...
Cell Death Genes Could Predict Survival in Esophageal Cancer, Study Finds
Researchers built a five-gene PANoptosis-based risk model and nomogram that predict survival, immune landscape, and treatment sensitivity in esophageal cancer ...
The Don’t Eat Me Signal: How CD47 Shapes Cell Clearance in Cancer, Heart Disease and the Brain
A new review details how the CD47 don't eat me signal regulates efferocytosis and shapes disease outcomes in cancer, atherosclerosis ...
Cell Death Protein GSDME Emerges as Ominous Sign for Gastric Cancer Patients
New research shows that the pyroptosis executor GSDME is upregulated in gastric cancer, where it correlates with advanced stage, immunosuppressive ...
Scientists Uncover Why a Key Antitumor T Cell Loses Its Fight in Ovarian Cancer
A new study links CEACAM1 expression and dysregulated SHP-1, LCK, and ZAP70 signaling to the functional exhaustion of follicular cytotoxic ...
How Sleep Apnea and Obesity May Quietly Fuel Cancer Growth
A new perspective in the International Journal of Obesity argues that obesity, obstructive sleep apnea, and cancer form an interconnected ...
Immune ‘Don’t Eat Me’ Protein CD47 Drives Chemotherapy-Induced Heart Aging in Male Mice
New research shows that the immune checkpoint protein CD47 rises in doxorubicin-damaged hearts and that blocking it with an antibody ...
Immune Checkpoint VISTA Doubles as a Growth Engine Inside Mesothelioma Cells
New research shows the immune checkpoint molecule VISTA also drives proliferation within mesothelioma cells through RIPK1-associated and AKT-dependent signalling, making ...
VISTA: The Myeloid Checkpoint Rewriting the Rules of Cancer Immunotherapy
A new review argues that the immune checkpoint VISTA acts as a myeloid-centered axis in tumors, offering a route past ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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