How Histone Tweaks Help Deadly Fungi Evade Drugs and Hosts
A new review in Current Genetics details how histone methylation, acetylation, and demethylation regulate virulence, stress responses, and drug resistance ...
Tag: histone acetyltransferase
HAT1 Emerges as a Driver of Glioblastoma Growth and Drug Sensitivity
A multi-omics study identifies the epigenetic regulator HAT1 as upregulated in glioblastoma, where its inhibition slows tumor growth and boosts ...
p300 activity and cellular location track breast cancer aggressiveness
Experimental p300 inhibition reduced breast cancer cell survival and spread, while cytoplasmic localization in patient tumors was associated with lower ...
Fungal enzyme RTT109 proves essential for inheriting silenced chromatin
A new study in Neurospora crassa shows that the replication-linked histone acetyltransferase RTT109, acting independently of its known product H3K56 ...
Blocking EP300 Rewires Scar-Associated Macrophages to Fight Acute Liver Failure
A new Nature Communications study shows that inhibiting the epigenetic enzyme EP300 restores the antibacterial function of scar-associated macrophages by ...
Phase-Separation Discovery Reveals How a Key Gene-Regulating Complex Assembles Itself
New research shows that the scaffolding protein KANSL1 forms liquid-like condensates that assemble the NSL chromatin complex and drive the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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