RNA-processing enzyme Star-PAP stabilizes insulin receptor mRNA and guards fat tissue
A rare Star-PAP variant found in lean individuals led researchers to discover that this polyadenylation enzyme stabilizes insulin receptor mRNA ...
Tag: histone acetylation
Astragaloside IV Eases Fatty Liver by Epigenetically Silencing a Lipogenesis Switch
A new preclinical study reports that the Astragalus compound astragaloside IV reduces hepatic fat accumulation in mice and human liver ...
Epigenetic switch drives ERK signaling in glioblastoma, study finds
A study identifies an SP1/P300/TRAF3IP3 signaling axis that links promoter-specific chromatin remodeling to persistent ERK activation in glioblastoma.
Metabolic Enzyme BCAT1 Drives Endometriosis Cell Growth Through Histone Acetylation
A cell study finds that the enzyme BCAT1, elevated in endometriosis tissue, promotes proliferation and migration of ectopic endometrial stromal ...
Cryo-EM reveals dual DNA and histone binding by cancer-linked BRD4
Penn State researchers found that cancer-linked BRD4 can bind nucleosomes through both DNA contacts and recognition of modified histones, challenging ...
DDIT4 protein worsens artery narrowing by disrupting smooth muscle cell metabolism
A Nature Communications study shows that the protein DDIT4 drives vascular smooth muscle cell switching and artery thickening in mice ...
Cell study links resveratrol glucoside to mitochondrial and chromatin changes in senescence
An in-vitro study found that resveratrol glucoside reduced senescence-associated cellular changes by altering mitochondrial metabolism and chromatin regulation while showing ...
Gut Microbes and Lung Cancer: Genes Point to Six Suggestive Links, But Butyrate Experiments Steal the Show
A Mendelian randomization study of 119 gut microbial genera finds six suggestive inverse associations with non-small cell lung cancer risk, ...
Fungal enzyme RTT109 proves essential for inheriting silenced chromatin
A new study in Neurospora crassa shows that the replication-linked histone acetyltransferase RTT109, acting independently of its known product H3K56 ...
Aging Gut Microbes Weaken Flu Defenses, but Acetate Restores Protection in Old Lung Cells
New research in Aging Cell shows that age-related gut microbiota dysbiosis reduces acetate production and weakens antiviral defense in the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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