Hot Flash Drug Elinzanetant Shows Strong Safety Record in Pooled Analysis of Four Clinical Trials
A pooled analysis of four randomized trials found the dual neurokinin receptor antagonist elinzanetant showed no liver toxicity or cancer ...
Tag: hepatotoxicity
Pennyroyal Oil Disrupts Hormones and Damages Liver and Fertility in Rats
A combined computational and rat study shows that pulegone-rich pennyroyal essential oil damages the liver and disrupts fertility through endocrine ...
Proteomics and machine learning expose hidden toxicity in protein degrader drugs
High-throughput proteomics and machine learning revealed that cereblon-recruiting androgen receptor degraders inhibit mitochondrial complex I, and guided linker modifications that ...
Chia Seeds Outshine Vitamin E in Shielding Mice From Grill-Smoke Carcinogen Damage
A new mouse study found that whole chia seeds protected against benzopyrene-induced liver and metabolic damage more effectively than vitamin ...
Root Versus Leaf: Why the Plant Part in Your Ashwagandha Supplement Matters for Safety
A new review finds that ashwagandha root and leaf differ profoundly in chemistry, clinical evidence, and safety, with major implications ...
Ugandan Medicinal Plants Show Hidden Liver Risks in Rat Safety Tests
A new rat study finds that three Ugandan plants used against bacterial skin infections are safe in single doses but ...
Common Medicinal Herb Shields Rat Livers and Kidneys From Fluoride Damage
A new rat study shows that extracts of the medicinal herb Phyllanthus amarus restore antioxidant defenses and reduce DNA fragmentation ...
Horned Melon Extract Shows Liver Risk in Mice After Prolonged Use
A new mouse study finds that the ripe fruit of Cucumis metuliferus is safe as a single dose but may ...
T Cell-Engaging Antibody Clears Aging Cells in Mice and Monkeys, With Liver Enzymes as a Built-In Safety Gauge
A uPAR-targeting bispecific T-cell engager safely cleared senescent cells in aged mice and rhesus macaques, with serum liver enzymes serving ...
Two Common Food Molds, One Hidden Threat: Mycotoxin Mix Silently Damages Rat Kidneys
A new rat study finds that combined exposure to aflatoxin and ochratoxin A causes chronic kidney damage that standard blood ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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