Platinum Chemotherapy, Not PARP Inhibitors, Emerges as the Main Driver of Blood Clone Expansion
New research shows carboplatin drives the expansion of TP53-mutant blood clones far more strongly than PARP inhibitors, while inherited homologous ...
Tag: hematopoietic stem cells
Two Master Genes That Decide Whether Blood Cells Are Born or Turn Cancerous
A new review details how the Runx1 and Gata2 transcription factors architect the epigenetic landscape of blood formation and how ...
Stem Cell Transplant Outperforms Drug Therapy for Younger Middle-Aged Aplastic Anemia Patients
A multicenter retrospective study finds that haploidentical stem cell transplantation achieves deeper and more durable responses than immunosuppressive therapy plus ...
AI Reads the 3D Architecture of Chromatin to Predict Stem Cell Aging
A compact convolutional neural network called ChromAgeNet can distinguish young from aged hematopoietic stem cells using 3D DAPI-stained microscopy images ...
Hidden Scars in the Bone Marrow: Clonal Hematopoiesis Rewrites the Niche Before Cancer Strikes
Single-cell and spatial analyses of human bone marrow reveal that clonal hematopoiesis of indeterminate potential is marked by fibroblast expansion, ...
Stem Cell Transplant Cured a Girl’s Leukemia but Left Her Friedreich Ataxia Unchanged
A decade-long case report shows that allogeneic stem cell transplantation cured a Friedreich's ataxia patient's leukemia and normalized her blood ...
Alzheimer’s Disease Sabotages the Bone Marrow, Starving the Brain of Healing Immune Cells
A new Nature Neuroscience study shows that Alzheimer's disease disrupts bone marrow monocyte production through chronic type I interferon signaling, ...
Kidney Damage Doesn’t Rule Out Transplants for Myeloma Patients, Brazilian Study Shows
A Brazilian study of 53 myeloma patients with renal impairment shows autologous stem cell transplantation carries high toxicity and intensive ...
Interferon-α Rewrites Clonal Competition in Human Blood Development
Single-cell multiomics of blood stem cells from myeloproliferative neoplasm patients shows that interferon-α normalizes blood counts by boosting lymphoid differentiation ...
Maladaptive Trained Immunity May Drive Inflammaging Through Hematopoietic Stem Cells
A new study in Nature Aging is drawing attention to a possible biological engine behind inflammaging—the chronic, low-grade inflammation that ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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