A single-nucleus transcriptomic atlas of human inner ear development
Researchers have built a single-nucleus transcriptomic atlas of the developing human inner ear, revealing that Hedgehog signaling repression is required ...
Tag: Hedgehog signaling
Two Cancer Genes Pull in Opposite Directions in Papillary Thyroid Tumors
A study of 125 papillary thyroid cancer patients finds that EGFR and GLI1 are both upregulated in tumors but inversely ...
Cellular Antenna Turned Metabolic Command Center: How Primary Cilia Reshape Health and Disease
A new review redefines the primary cilium as a dynamic sensory-metabolic hub whose disruption contributes to cardiovascular, reproductive, metabolic, cancer ...
Hedgehog-Responsive Perivascular Cells Emerge as Master Switches of Blood Vessel Repair and Disease
A new review synthesizes a decade of evidence showing that GLI1-positive perivascular cells act as state-dependent regulators of angiogenesis, capable ...
Computational Screen Flags Dozens of Risky Mutations in a Key Bone Growth Gene
A bioinformatics study screened 436 variants of the IHH gene and identified 53 mutations in its receptor-binding domain that may ...
The Hidden Lipid World That Keeps Cilia Working
A sweeping review in Advanced Science reveals that the lipid composition of ciliary membranes governs cilia assembly, motility, and Hedgehog ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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