Africa’s genetic diversity could transform global mental health research
A major new review argues that Africa's unmatched genetic diversity, combined with rising mental health needs and growing continental research ...
Tag: genome-wide association studies
New Tool HiFIseek Hunts Hidden Cancer Mutations in the Genome’s Dark Regulatory Regions
A new computational pipeline called HiFIseek systematically links damaging non-coding mutations to cancer genes, revealing that regulatory regions of drivers ...
New Nanoscale Genome Mapping Tool Pinpoints Causal Autoimmunity Variants
An Oxford-developed single-allele chromatin mapping platform called MCCv identifies causal noncoding variants in autoimmune disease and reveals that a neo-CTCF ...
One Obesity Gene Variant Rewires Nearly 100 Genes in Fat Cells, Study Finds
Researchers combined single nucleus RNA-sequencing with GWAS and UK Biobank data to show that an obesity-linked variant in SREBF1 allele-specifically ...
New Sparse Regression Method Tames Biobank-Scale Genetic Data for Risk Prediction
Researchers have adapted a two-stage sparse regression method called uniLasso to the UK Biobank, producing polygenic risk scores that match ...
Machine Learning Framework Distills Crohn’s Disease Risk From Half a Million Genetic Variants
A hybrid XGBoost-based machine learning framework has distilled Crohn's disease risk prediction down to just 15 genetic variants, achieving over ...
Massive Immune Cell Atlas Traces How Genetic Variants Drive Disease From Chromatin to Gene Expression
Researchers have built a population-scale single-cell atlas of ten million immune cells that traces how disease variants act through chromatin ...
Wild Boar Meat Quality Research Maps Its Path From Genetics to Nutrition
A new bibliometric analysis of 423 publications charts how wild boar meat quality research evolved from scattered genetic studies into ...
Diverse Biobank Data Sharpen Genetic Risk Prediction Where It Matters Most
A new Nature Genetics study shows that the diversity of the All of Us Research Program improves polygenic risk score ...
APOE-Stratified Genome-Wide Study Reveals Hidden Genetic Architecture of Alzheimer’s Disease
A large APOE-stratified genome-wide association study reveals that Alzheimer's disease genetic risk variants have effects that are either amplified or ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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