CRISPR Antivirals Target Respiratory Viruses, but Lung Delivery Remains the Hurdle
A new review argues that CRISPR antivirals, especially RNA-targeting Cas13 systems, can suppress respiratory viruses in preclinical models, with lung ...
Tag: gene therapy
How Hippo, Wnt, NRG1 and Notch pathways could unlock heart regeneration
A new review synthesizes the signaling pathways, extracellular matrix cues, metabolic switches and transcription factors that govern cardiomyocyte proliferation and ...
Compact engineered Cas12m enables multiplexed CRISPR gene activation in mice
An engineered compact Cas12m variant enables multiplexed CRISPR gene activation from a single AAV vector in mouse models.
Neuronal SORT1 Protein Shields Brain Cells From Alzheimer’s Damage in New Study
A new study finds that the neuronal protein SORT1 preserves endosomal balance, calms microglial inflammation and improves cognition in Alzheimer's ...
Circular RNA aptamers recruit natural ADAR1 to edit RNA with near-perfect efficiency
A new RNA editing platform called MARRS recruits the cell's own ADAR1 enzyme with engineered circular RNA aptamers, achieving up ...
Patients weigh promise and peril of gene therapies for inherited heart disease
A qualitative study of 21 adults with familial cardiomyopathy finds that perceived disease severity, family history and safety uncertainties shape ...
Biomaterials and smart drug delivery aim to heal stubborn diabetic foot ulcers
A new review details how biomaterials, nanocarriers, gene-activated matrices and smart biosensor dressings are being engineered to restore angiogenesis and ...
Portland State virologists win $1 million NSF grant to trace crucivirus evolution
A three-year, $1 million National Science Foundation grant will fund Portland State University's eXtreme Virus Lab in its targeted search ...
Stroke Prevention in Sickle Cell Disease Still Rests on Decades-Old Trials
A systematic review of 58 studies finds that transfusion-based stroke prevention established by the STOP trials remains the cornerstone for ...
CRISPR gene therapies face a reckoning with off-target genome edits
A new review maps the molecular, computational and experimental landscape of off-target CRISPR editing as gene therapies advance toward the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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