Gene Therapy

Credit: Mary Ann Liebert, Inc., publishers New Rochelle, NY, September 28, 2020—Life-threatening cardiac arrhythmias can be linked to the functional and structural consequences of gene mutations. The study is published in the…

From fundamental research to therapeutic advances, no less than 32 communications (e-posters and talks) will be presented by the scientific experts of the Institute of Myology. Among the selected papers, two important breakthroughs will…

New study deploys advanced tools to retrace 1,000 years of African pastoralist cattle breeding, identifying traits to help cattle survive blistering heat, drought and advancing diseases (Nairobi, Kenya, September 28, 2020)--Scientists…

Credit: Courtesy Civelek lab New research is revealing how genetic differences in the fat in men's and women's bodies affect the diseases each sex is likely to get. University of Virginia researchers Mete Civelek, PhD, Warren…

Variation in just three brain genes predicts how well a medication will work in treating a patient with alcohol use disorder, report Medical University of South Carolina researchersCredit: Medical University of South Carolina …

Researchers from the Structural Bioinformatics and Network Biology Laboratory at IRB Barcelona develop a system to predict tumour response to different treatments.Credit: SBNB lab (IRB Barcelona) Cancer driver genes are those with…

Credit: CNIO Capecitabine is a chemotherapy drug used for breast and colorectal Cancer cancer. It can extend survival rate by nearly 10%. However, recent studies revealed that almost 50% of patients develop palmar-plantar…

Participants with advance non-small cell lung cancer and colorectal cancer experienced the greatest benefits in this first-in-human study DUARTE, Calif. -- A phase 1 clinical trial of sotorasib (AMG 510) in patients with heavily pretreated…

Credit: Mary Ann Liebert, Inc., publishers New Rochelle, NY, September 18, 2020—Gene therapy was successfully used to overcome the cardiac effects of Freidreich’s ataxia (FA) in a mouse model of the disease, as reported in the…

Credit: N/A Fruit flies have the uncanny ability to wake up from a months-long hibernation right when their food of choice--say, the fruit from apple or Hawthorn trees--is at its peak. They're active for a couple of weeks, eating and…

New technology cuts down on cell culture time by half and uses more targeted cell sorting and purification methodsCredit: Singapore-MIT Alliance for Research and Technology (SMART) Singapore, 14 September 2020 - Researchers from…

Credit: Children's Medical Research Institute, Westmead, Sydney Australia A new publication by scientists from Children's Medical Research Institute has challenged one of the foundations of the gene therapy field and will help to…

If evolution selects for the fittest organisms, why do we still have imperfections? Scientists at the Milner Centre for Evolution at the University of Bath investigating this question have found that in species with small populations,…

Credit: CNIO The KRAS oncogene is involved in at least one fifth of all human cancers: KRAS mutations are directly responsible for 32% of lung tumours and 96% of pancreatic tumours. However, after more than thirty years of research…

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, affecting 1 in 250 people. The disease is characterised by an increase in size of the left ventricle of the heart. The stretched heart muscle is then unable to pump blood…

Credit: Dr Jie Zheng An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit (MRC-IEU) at the University of Bristol, has demonstrated how genetic data can be used to…

Credit: University of Pittsburgh PITTSBURGH, Sept. 3, 2020 - Gene therapy generally relies on viruses, such as adeno-associated virus (AAV), to deliver genes into a cell. In the case of CRISPR-based gene therapies,…

ERC funding for pioneering researchCredit: David Ausserhofer/ MDC Dr. Kathrin de la Rosa and Dr. Ilaria Piazza, who are both junior group leaders at the Max DelbruÌck Center for Molecular Medicine in the Helmholtz Association (MDC),…

Credit: Mary Ann Liebert, Inc., publishers New Rochelle, NY, September 2, 2020—A meta-analysis of non-human primate (NHP) studies showed that adeno-associated virus (AAV) gene therapy often caused dorsal root ganglion (DRG) pathology.…

Collaboration co-led by Keck School of Medicine of USC aims for safe, effective treatment inspired by rare cases of HIV cureCredit: Richard Carrasco An HIV research program led by scientists at USC and the Fred Hutchinson Cancer…