T-Cell Activation State Reshapes Asthma Genetics and Points to New Drug Targets
A large genetic analysis shows that asthma-linked gene regulation in CD4+ T cells changes with activation state, exposing dozens of ...
Tag: Gene regulation
Chaperone protein guides histone H1 to its nucleosome target, study reveals
Single-molecule experiments show that linker histone H1, essential for compacting and silencing genes, can bind and slide along DNA but ...
New AI Framework Reads and Rewrites Cell Trajectories Inside Living Tissue
A new deep generative and agent-based framework called veloAgent integrates spatial context into RNA velocity analysis, producing anatomically consistent cell ...
How Cells Build Their Protein Shredder: New Rules of Proteasome Biogenesis
A new review argues that mammalian cells regulate the construction of their proteasomes through layered transcriptional networks and assembly pathways, ...
Single Regulatory Protein Supercharges Hydrogen Production in Deep-Sea Archaeon
Overexpressing the regulatory protein EnfR in the hydrogen-producing archaeon Thermococcus onnurineus NA1 boosts formate-dependent growth and hydrogen output by rebalancing ...
Epigenetic Editing Steps Closer to the Clinic as Bioengineering Tools Mature
The EpiBio-24 conference in Amsterdam showcased maturing epigenetic engineering tools, durable gene silencing in animal models, and growing clinical momentum ...
Scientists Find a Single Gene Switch That Could Unlock Stubborn Soybean Transformation
Researchers in China have identified the transcription factor GmRAMOSA1 as a key regulator of adventitious shoot regeneration in soybean, showing ...
Hidden Genetic Switch Links Cleft Lip Risk Gene to Neural Crest Cells
New research shows that the cleft lip and palate risk gene IRF6 is directly controlled by the transcription factor SOX9 ...
Open Chromatin Is Not So Open: Active Genes Ride on Condensed Domains
New simulations reveal that euchromatin is mostly condensed into dense domains, with short active regulatory regions protruding on their surfaces ...
Tiny DNA Insert in a Super-Enhancer Fine-Tunes Two Cancer Genes in Breast Tumors
A common germline insertion within a bifunctional super-enhancer dampens the expression of the cancer-promoting genes LINC00636 and CD47 in breast ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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