Cohesin keeps compact active genome domains from mixing in living cells
Live-cell super-resolution imaging in human cells shows that active euchromatin forms compact dynamic domains and that the cohesin complex prevents ...
Tag: Gene regulation
Cohesin Loops, Baciptosis, Microexons: MSK Studies Illuminate Gene Control and Immunity
New research from Memorial Sloan Kettering Cancer Center reveals how cohesin activates distant genes, identifies an immunogenic cell death called ...
Wheat’s Hidden Genome: New Framework Aims to Turn Untapped DNA Diversity into Predictive Breeding
A new review proposes the Pan-Genome to Pan-Phenome framework, a conceptual roadmap for translating hidden wheat genomic variation such as ...
AlphaGenome Atlas Predicts Effects of Billions of DNA Changes
AlphaGenome Atlas provides AI-generated predictions for more than 9 billion possible single-letter DNA changes across hundreds of human cell types ...
TWAS sign errors reach 33% in complex-trait analyses
A Nature Genetics analysis estimated that TWAS assigns the wrong effect direction to 23% of plasma-protein associations and 33% of ...
Kallmann family study finds PROK2 upregulation with uncertain ANOS1 variant
A study of two Polish brothers with Kallmann syndrome identified an uncertain-significance ANOS1 variant and concordant PROK2 upregulation in blood, ...
Research report: The regulatory role of DzERF94 in carotenoid biosynthesis during ripening in durian (Durio zibethinus) pulp
A four-cultivar durian study links DzERF94 and DzLCYE expression during ripening to lutein accumulation, while tomato assays show that DzERF94 ...
GnRH1 and estrogen regulate chicken pituitary GRP expression
Cultured chicken pituitary cells showed that GnRH1 increased gastrin-releasing peptide expression, while estradiol enhanced it through two potential estrogen-receptor-binding sites ...
GLIS3 regulates astrocyte differentiation in human stem cells
Experiments in mouse-derived astrocytes and human embryonic stem cells identify GLIS3 as an upstream regulator of astrocyte differentiation and neural ...
Defective HIV proviruses reprogram T cells at selected integration sites
A cellular study shows how transcriptionally active defective HIV proviruses can reprogram CD4 T cells through integration-site-specific effects on host ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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