Long Non-Coding RNA MALAT1 Emerges as a Multifaceted Regulator of Bone Remodeling
A new narrative review synthesizes preclinical evidence that the long non-coding RNA MALAT1 influences osteoblast differentiation, osteoclast formation and bone ...
Tag: gene expression regulation
New Genetic Atlas Reveals DNA Changes That Made Humans Vulnerable to Osteoarthritis
When the human genome was first sequenced, one of the most striking findings was how little separates us from our ...
Massive RNA Dataset Uncovers Hidden Genetic Switches Behind Gene Expression
A large-scale analysis of TOPMed RNA sequencing data shows that most genes are controlled by multiple independent regulatory switches that ...
New Tool HiFIseek Hunts Hidden Cancer Mutations in the Genome’s Dark Regulatory Regions
A new computational pipeline called HiFIseek systematically links damaging non-coding mutations to cancer genes, revealing that regulatory regions of drivers ...
Cells Read Their Neighbors to Pinpoint Their Own Position in the Embryo
An information-theoretic study shows that gene expression in a cell's immediate neighbors supplies the missing positional information needed to uniquely ...
Weight Loss Rewires Cholesterol Metabolism, but Tiny RNAs Are Not the Driver
A Dutch randomized trial finds that diet-induced weight loss shifts cholesterol metabolism in abdominally obese men from a synthesizing to ...
Evolved Lantern Tool Lights Up RNA and Protein Neighbors in Living Cells
Researchers have used directed evolution to engineer Lantern into a faster enzyme capable of labeling both RNA and protein neighbors ...
Scientists Hail Epigenetic Editing as Safer Than Gene Editing, Yet Harbor Private Doubts
A new interview study finds that scientists broadly promote epigenetic editing as a safer alternative to gene editing while privately ...
Balanced mRNA and ribosome levels govern growth in eukaryotic cells
A new study in budding yeast suggests that one of biology’s most fundamental processes—cell growth—may be governed by a remarkably ...
Alternative splicing could reveal proteins’ hidden functions
A new computational study is turning the spotlight on one of biology’s most difficult questions: why can two protein isoforms ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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