Cataract Clouding in Diabetes Traced to a DNA-Sensing Inflammatory Chain Reaction
Researchers at Sun Yat-sen University show that blocking the cGAS-STING pathway and the NLRP3 inflammasome reduces inflammatory cell death and ...
Tag: gasdermin D
How Exercise Trains the Immune System to Fight Infection
New research in PLOS Pathogens reveals that exercise drives a protective metabolite pathway that pushes the NLRP3 inflammasome into a ...
Trojan Horse Inhibitors Slip Through Gasdermin Pores to Shut Down Pyroptosis
New research shows that gasdermin D pores formed during pyroptosis can admit selectively designed caspase inhibitors, allowing the inflammatory cell ...
Overactive Inflammasome in Artery Muscle Cells Drives Dangerous Vessel Thickening in Mice
A new mouse study shows that hyperactive NLRP3 inflammasome signaling within vascular smooth muscle cells drives inflammation, pyroptosis, lipid accumulation, ...
Plant Compound Salvianolic Acid B Shields Heart Cells From Sugar-Driven Inflammatory Cell Death
New research shows that salvianolic acid B, a polyphenol from red sage, protects human heart muscle cells from high-glucose injury ...
Inflammatory Cell Death Emerges as a Driver of Ovarian Dysfunction and Infertility
A new review in Reproductive Sciences details how the inflammatory cell death pathway pyroptosis drives ovarian dysfunction and infertility, and ...
Tiny RNA Molecule Triggers Explosive Cell Death in Aggressive Breast Cancer
Researchers have discovered that the microRNA miR-205-3p triggers inflammatory pyroptotic cell death in triple-negative breast cancer by repressing HSP90AB1, while ...
How Microglial Metabolism and Mitochondria Drive Brain Damage After Stroke
A new review integrates mitochondrial quality control, metabolic reprogramming, and NLRP3 inflammasome activation into a single framework explaining how microglia ...
Innate Immune Sensors in Focus: Structural Insights into Inflammasomes and PANoptosomes Open New Therapeutic Avenues
A Cell Research review synthesizes structural and mechanistic insights into inflammasomes and PANoptosomes, revealing how innate immune sensors assemble inflammatory ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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