Hidden Heart Fibroblast State Found Across Human DCM Datasets
A reanalysis of two public single-nucleus RNA-sequencing cohorts identifies a MEOX1-positive, FAP-positive, relatively ACTA2-low fibroblast state that is reproducibly enriched ...
Tag: fibroblasts
Skin Biopsy Outperforms Invasive Surgery in Global Mitochondrial Disease Study
An international study shows that functional testing on cells grown from a small skin biopsy can diagnose mitochondrial disease, often ...
New Pathway Identified in Keloid Formation
Researchers identify the CD147-CENPF signaling pathway as a key driver of keloid formation, offering a new target for treating this ...
Gastric Cancer Cells and Fibroblasts Locked in a Deadly Mutual Promotion Loop
Scirrhous gastric cancer is among the most feared forms of stomach malignancy, distinguished by rapid infiltration of cancer cells through ...
Fibroblast collagen signal drives gut scarring and cancer in inflammatory bowel disease
A single-nuclei study reveals how CXCL14+ fibroblasts and SPP1+ macrophages form a collagen IV-driven feedback loop that promotes fibrosis and ...
Mitochondrial morphology and mtDNA content in fibroblasts from patients with different types of mucopolysaccharidosis
For decades, the biological story of mucopolysaccharidoses — a family of rare, inherited metabolic disorders — has centered on the ...
Faulty Connexin 43 Gene Reveals Hidden Signaling Switch Behind Rare Bone Disorder
A new study shows that GJA1 mutations in oculodentodigital dysplasia suppress Wnt/c-MYC signaling, driving a paradoxical inflammatory imbalance and excessive ...
Hypertensive Stress Rewires Immune Cell Signals in a Common Heart Failure Syndrome Independent of Obesity
A new study shows that hypertensive stress rewires cardiac macrophage signaling, impairing metabolic support for heart muscle cells while driving ...
Single-Cell Sequencing Reveals Why Diabetic Foot Ulcers Refuse to Heal
A new review details how single-cell RNA sequencing is exposing the cellular and molecular failures that keep diabetic foot ulcers ...
Cell Maps of Endometriosis Reveal Nerve and Immune Hubs That May Drive Pain
A high-resolution spatial transcriptomic atlas of human ovarian and peritoneal endometriosis lesions reveals conserved fibroblast niches and sensory neuroimmune interactions ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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