Genetic screening links four circulating proteins to intervertebral disc disorders
A local genetic screen linked MST1, DLK1, ITIH1 and SAA1 to intervertebral disc-disorder outcomes, while single-cell tissue analysis and a ...
Tag: ferroptosis
Tubocapsenolide A Disrupts PLK1-Linked Damage Clearance in Oxaliplatin-Resistant Colorectal Cancer
A preclinical study finds that tubocapsenolide A inhibits PLK1, disrupting ESCRT-mediated damage clearance and restoring oxaliplatin sensitivity in resistant colorectal ...
Mechanisms by which programmed cell death mediates immune evasion and antitumour immunity in oropharyngeal cancer
A review finds that programmed cell death can promote immune evasion or antitumour immunity in oropharyngeal cancer depending on pathway ...
Astragaloside IV Emerges as a Candidate Ferroptosis Link in Heart Hypertrophy
Astragaloside IV reduces pathological cardiac hypertrophy and suppresses ferroptosis in separate models, but direct experiments are needed to establish whether ...
Turning Off a Cancer Cell’s Survival Switch: How NRF2 Controls Ferroptosis in Targeted Therapy
A new review details how the NRF2 transcription factor shields cancer cells from iron-dependent ferroptotic death and how natural and ...
Stem Cell Exosomes Carry a MicroRNA That Halts Kidney Scarring
Chronic kidney disease is a slow-motion catastrophe. Millions of people live with kidneys that are quietly being replaced by scar ...
Heat-Stressed Fish Livers Rework Bile Acids to Survive Warming Seas
A seven-day heat stress experiment reveals how farmed golden pompano livers mobilize antioxidant defenses, suppress immunity, and remodel bile acid ...
Hypoxia-Driven Mitochondrial Enzyme Helps Pancreatic Cancer Evade Ferroptosis and Resist Gemcitabine
A new study links tumor hypoxia to ferroptosis suppression via SQOR-mediated coenzyme Q reduction, offering a potential strategy to overcome ...
Mitochondria emerge as the central hub linking cell death and metabolism in gum disease
A new review proposes that mitochondrial collapse drives a self-reinforcing cycle linking ferroptosis and metabolic reprogramming in periodontitis, opening the ...
Persister cells hiding in minimal residual disease drive cancer relapse
A new review outlines how drug-tolerant persister cells hidden within minimal residual disease drive cancer relapse and how pathway inhibitors, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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