Calcium Channel TRPV4 Emerges as a Key Player in Marfan Syndrome Aortic Disease
A new study identifies the mechanosensitive calcium channel TRPV4 as a top candidate driving the inflammatory and remodeling behavior of ...
Tag: extracellular matrix remodeling
New FBP1 target and asiatic acid hydrogen sulfide donors speed diabetic wound healing
Diabetes affects hundreds of millions of people worldwide, and roughly one in four of them will face a complication that ...
Targeting IL-11-driven tissue stiffening may slow ovarian aging
Scientists have identified a previously underappreciated driver of female reproductive aging—the progressive stiffening of the ovarian extracellular matrix under the ...
Losing desmoplakin in lung epithelium triggers fibrotic Wnt signaling in vitro
Idiopathic pulmonary fibrosis has long been framed as a disease of runaway wound healing, in which the delicate air sacs ...
Maple Leaf Extract Shields Egg Production From Oxidative Stress
A dietary supplement of Acer truncatum leaf extract protected laying hens from oxidative-stress-induced ovarian damage by activating Nrf2 antioxidant defense ...
Single-Cell Multi-Omics Reveals Cancer-Associated Fibroblast Programs in Breast Cancer
A groundbreaking study has unveiled new insights into the complex biology of cancer-associated fibroblasts (CAFs) within triple-negative breast cancer (TNBC), ...
O-GlcNAcylation of UGDH: New Immunometabolic Insights
In a groundbreaking stride toward unraveling the intricate web of immunometabolic regulation, a team of scientists led by Wu, Lei, ...
Colorectal Cancer Cells Stimulate Collagen Production in Cancer-Associated Fibroblasts Through TGF-β1-Triggered Glycine Synthesis: PHGDH Emerges as a Potential Therapeutic Target
Colorectal cancer (CRC) remains a formidable challenge in oncology, representing one of the most prevalent and deadly malignancies worldwide. Despite ...
Deep Learning Predicts Stretch Impact on MMP-2
In a groundbreaking advance at the intersection of mechanobiology and artificial intelligence, researchers have unveiled a novel deep learning-based predictive ...
ADAMTS9 Cleaves TMEM67, Disrupting Wnt and Cilia
In a groundbreaking study published in Nature Communications, a team of researchers led by Ahmed, Fischer, and Robert has unveiled ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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