T cell enhancer reaches across genome domains to tune distant genes
Deleting the Tcra enhancer revealed that it selectively regulates two distant genes across a TAD boundary while leaving closer neighboring ...
Tag: enhancer-promoter interactions
Rumpelstiltskin Protein Guards Genome Boundaries in Fruit Flies
A new study finds that the Drosophila protein Rumpelstiltskin maintains the Homie insulator barrier and shapes Polycomb domain interactions in ...
Deep learning model predicts multiple chromatin interaction types from DNA sequence
UniLoopNet predicts enhancer–promoter, enhancer–enhancer, CTCF-mediated, and stripe-associated chromatin interactions from DNA sequence using a multi-task deep learning framework.
Cohesin Loops, Baciptosis, Microexons: MSK Studies Illuminate Gene Control and Immunity
New research from Memorial Sloan Kettering Cancer Center reveals how cohesin activates distant genes, identifies an immunogenic cell death called ...
New Nanoscale Genome Mapping Tool Pinpoints Causal Autoimmunity Variants
An Oxford-developed single-allele chromatin mapping platform called MCCv identifies causal noncoding variants in autoimmune disease and reveals that a neo-CTCF ...
Deep Learning Tool Reads Leukemia’s Regulatory Code to Predict Patient Risk
A new deep learning framework called TERfinder integrates multi-omics data to map enhancer-promoter interactions in myeloid leukemia, pinpointing key regulatory ...
Epigenetic Editing Steps Closer to the Clinic as Bioengineering Tools Mature
The EpiBio-24 conference in Amsterdam showcased maturing epigenetic engineering tools, durable gene silencing in animal models, and growing clinical momentum ...
New R Package ChIPSP Maps Gene Regulation in 3D, Revealing Hidden Cancer Targets
Researchers have developed ChIPSP, an R package that combines ChIP-seq with Hi-C chromatin loops to identify transcription factor target genes ...
MIT Researchers Reveal How Chromatin Dynamics Regulate Gene Expression
In a groundbreaking study led by researchers at the Massachusetts Institute of Technology (MIT), the intricate dynamics of chromatin within ...
Inside the Human 4D Nucleome Blueprint
In a groundbreaking study recently published in Nature, researchers have unveiled intricate connections between the spatial organization of the human ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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