Framework Separates DNA-Sensing Claims by Cell Type and Disease Stage
A focused review finds that cGAS–STING and AIM2 claims in atherosclerosis depend on the DNA source, cellular lineage, disease stage ...
Tag: endothelial dysfunction
Computer model finds timing and dose govern simulated endothelial repair
A multiscale simulation found that endothelial repair depended on early, moderate AKT activation and on balancing local nitric oxide production ...
Maternal high-fat diet before pregnancy may program offspring heart disease risk
A new review synthesizes evidence that maternal high-fat diet before and during pregnancy may program offspring coronary artery disease risk ...
How Broken Body Clocks and Iron-Driven Cell Death May Fuel Hypertension
A new review proposes that circadian disruption may lower the threshold for iron-driven ferroptotic cell death in blood vessels and ...
Hypertensive Stress Rewires Immune Cell Signals in a Common Heart Failure Syndrome Independent of Obesity
A new study shows that hypertensive stress rewires cardiac macrophage signaling, impairing metabolic support for heart muscle cells while driving ...
Sirtuin 1 emerges as the molecular switch linking cellular senescence to heart failure
A new review argues that the longevity enzyme sirtuin 1 sits at the molecular crossroads between cellular senescence and heart ...
ApoE4 May Raise Risk of Cognitive Decline From Small Vessel Disease, Review Finds
A new narrative review argues that ApoE4 acts as a context-dependent susceptibility modifier in cerebral small vessel disease rather than ...
Biologic Therapy May Reshape Blood Clot Risk in Hidradenitis Suppurativa Over Time
A new retrospective study examines how venous thromboembolism risk changes over the course of biologic therapy in patients with hidradenitis ...
STK39 Emerges as a Molecular Clue in Moyamoya Disease Under Hypoxic Stress
A new study links the kinase gene STK39 to endothelial dysfunction and inflammatory activation under hypoxic conditions in moyamoya disease, ...
USP28 enzyme drives deadly blood vessel damage in sepsis, mouse study reveals
Researchers identify a USP28–NMMHC IIA signaling loop that accelerates endothelial cell death and multi-organ injury in septic mice, revealing a ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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