MiR-145 emerges as a driver and biomarker of the fibrotic tumor microenvironment
A new study identifies miR-145 as a driver and biomarker of the fibrotic tumor microenvironment, linking NOTCH signaling, promoter hypomethylation, ...
Tag: EMT
Vimentin Emerges as a Powerful Prognostic Marker in Triple-Negative Breast Cancer
A retrospective cohort study from Indonesia's national referral hospital links vimentin expression to dramatically shorter survival in triple-negative breast cancer ...
When Healthy Cells Merge: Fusion Events Trigger Genome Chaos That May Ignite Cancer
New research shows that spontaneous fusion between non-malignant breast epithelial cells triggers catastrophic genomic instability, ploidy reduction and EMT-like traits, ...
Tiny Stem Cell Vesicles Loaded with miR-124 Strike Dual Targets to Curb Colorectal Cancer
Scientists engineered stem cell-derived vesicles to deliver tumor-suppressive miR-124 into colorectal cancer cells, silencing EZH2, weakening STAT3 signaling, and shrinking ...
Tiny Gene Regulators Show Promise Against the Deadliest Childhood Brain Tumors
New research shows that restoring the microRNAs miR-34a and miR-34c suppresses the survival, migration, invasion, and stemness of pediatric grade ...
How Cancer-Causing Viruses Hijack the Notch Signaling Pathway
A new review details how six major human oncoviruses dysregulate the Notch signaling pathway to drive proliferation, apoptosis resistance, and ...
Cigarette Smoke Sends a Cancer Signal: Exosomal circ55033 Drives Bladder Tumor Aggression
Researchers report that cigarette smoke drives bladder cancer aggressiveness through exosome-delivered circ55033, which sponges miR-1286 to promote EMT and cancer ...
The Hidden Switch That Helps Breast Cancer Survive and Resist Treatment
A comprehensive new review maps how NF-κB signalling drives breast cancer progression, subtype-specific therapy resistance and tumour-microenvironment crosstalk, and argues ...
Fat-Fuelled Tumours: How Lipid Droplets Drive Colorectal Cancer Aggression
New research shows that colorectal cancer cells absorb abundant circulating fatty acids, store them in lipid droplets and use them ...
ADAM17 Enzyme Drives Migration in Canine Mammary Tumor Cells, Study Finds
A new study in BMC Cancer shows that the protease ADAM17 is upregulated in aggressive canine mammary carcinomas and promotes ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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