How Shapeshifting Tumor Cells Outsmart Cancer Treatment
A new review explains how tumor cells reversibly switch identities through epigenetic and microenvironmental programs, driving metastasis and therapy resistance.
Tag: drug-tolerant persister cells
Lab-Grown Tumor Chips and AI Join Forces to Outsmart Glioblastoma
A new review in the Journal of Neuro-Oncology outlines how patient-derived tumor platforms such as organoids and organ-on-chip systems, combined ...
Enzyme GDH1 Keeps Breast Cancer Persister Cells Alive During Chemotherapy
New research shows that the mitochondrial enzyme GDH1 sustains drug-tolerant persister cells in triple-negative breast cancer by coordinating glutamine metabolism, ...
Calcium-Rich Bone Environment Helps Osteosarcoma Cells Survive Chemotherapy
Researchers have discovered that the calcium-rich bone microenvironment drives chemotherapy tolerance in osteosarcoma through an ORAI3–Ca²⁺–NFAT4–PINK1 mitophagy axis that can ...
Chemotherapy’s Hidden Survivors: Lactylation Switch Reveals How Colorectal Cancer Cells Hide From Treatment
A new Molecular Cancer study reveals how UQCRC2 lactylation and SIRT1-driven mitophagy allow colorectal cancer cells to survive chemotherapy in ...
Young Scientists Map the Next Quarter-Century of Cancer Research
Six emerging cancer researchers outline in a Nature Reviews Cancer anniversary viewpoint the technologies and paradigms that will shape oncology ...
Drug-Tolerant Persister Cells: From Lab to Clinic
In the relentless battle against cancer, the phenomenon of drug-tolerant persister (DTP) cells continues to pose a substantial challenge, complicating ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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