Genes, Big Data and a Protective Mutation Point to New Alzheimer’s Drug Targets
An integrated analysis of human genetics, patient-derived cell models and electronic health records has identified 19 Alzheimer's drug targets in ...
Tag: drug targets
Scientists Find Druggable Switch That Controls the Cell’s Master Recycling Regulator TFEB
A Nature study from TIGEM reveals a previously unknown TBK1-ULK1 signaling pathway that controls the master recycling regulator TFEB, exposing ...
Inducible dCas12a tool widens CRISPR gene control in malaria parasite
Researchers have built an inducible dCas12a-based CRISPRi/a system that dramatically expands gene regulation capabilities in the malaria parasite Plasmodium falciparum ...
Mathematical Model Reveals How Copper and Zinc Drive Alzheimer’s Plaque Formation
A Mississippi State mathematician has built a validated computational model showing how copper and zinc ions influence amyloid-beta plaque formation ...
Ovarian Cancer Cells May Fuel Themselves With Potent Adrenal Androgens
New research shows that high-grade serous ovarian cancer cells can convert abundant adrenal 11-oxyandrogen precursors into the potent androgen 11-keto-testosterone, ...
Genetic Study Pinpoints New Drug Targets for Common Mental Disorders
A combined Mendelian randomization and colocalization analysis of large genetic datasets has identified candidate drug targets for depression, anxiety, schizophrenia, ...
Ascites Proteins Reveal New Drug Targets for Peritoneal Cancer Spread
An integrative proteotranscriptomic analysis of malignant ascites from nearly 400 patients has uncovered novel paracrine therapeutic targets in peritoneal metastases, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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