Hidden Metabolite Switches on RNA Draw $5.5 Million NIH Transformative Award
Weill Cornell Medicine's Dr. Samie Jaffrey has received a five-year, $5.5 million NIH Director's Transformative Research Award to map how ...
Tag: drug targets
Hidden in inhibitory neurons: cell-type genetics reveals KCNIP2 as a candidate epilepsy drug target
A cell-type-resolved genetic screen shows that KCNIP2, a potassium-channel accessory protein, emerges as a protective candidate epilepsy drug target only ...
A Single-Celled Parasite Carries More Rab Genes Than Humans, and AlphaFold3 Reveals Why
A computational study reveals that the parasitic amoeba Entamoeba histolytica encodes more than ninety Rab GTPase genes whose predicted structures ...
Cryo-EM snapshots expose the molecular machine that keeps deadly tropical parasites alive
Researchers at the University of Liège and Rockefeller University have captured near-atomic-resolution cryo-EM structures of the trans-spliceosome, the essential RNA-processing ...
Massive RNA Dataset Uncovers Hidden Genetic Switches Behind Gene Expression
A large-scale analysis of TOPMed RNA sequencing data shows that most genes are controlled by multiple independent regulatory switches that ...
Scientists Uncover Hidden Protein Circuit That Keeps Chronic Pain Switched On
Boston University researchers found that blocking the protein RGS4 in sensory nerve cells allowed experimental models to recover from chronic ...
Massive Genetic Study Reveals New Molecular Targets for Bronchiectasis Across Ancestries
A trans-ancestry genome-wide association study of over 16,000 bronchiectasis cases combined with multi-omics analyses has pinpointed SERPINA1 as the strongest ...
Cellular Stress Switch IRE1α Emerges as Next-Generation Target for Type 2 Diabetes
A new review argues that the evolutionarily conserved IRE1α/XBP1 stress-signaling pathway, which governs protein folding, inflammation and insulin action, offers ...
Genes, Big Data and a Protective Mutation Point to New Alzheimer’s Drug Targets
An integrated analysis of human genetics, patient-derived cell models and electronic health records has identified 19 Alzheimer's drug targets in ...
Scientists Find Druggable Switch That Controls the Cell’s Master Recycling Regulator TFEB
A Nature study from TIGEM reveals a previously unknown TBK1-ULK1 signaling pathway that controls the master recycling regulator TFEB, exposing ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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