Patient-derived CRC-X1 cell line supports colon cancer liver-metastasis research
A patient-derived colon cancer liver-metastasis cell line, CRC-X1, was stably passaged through 59 generations, formed tumors in 60% of mouse ...
Tag: drug sensitivity
Coagulation-associated genes stratify acute myeloid leukemia and spotlight SPINT2
An integrated transcriptomic and laboratory study linked coagulation-associated gene activity to survival and immune states in acute myeloid leukemia, while ...
New AI Framework Maps Drug Sensitivity Down to Individual Cells in Bulk Tumor Samples
A new two-step machine-learning framework called CLIMB and CLIFF computationally deconvolves bulk RNA-seq and drug sensitivity data into cell-type and ...
Telomere-Linked Senescence Genes Predict Survival in Cervical Cancer, Study Finds
A new bioinformatic study in Reproductive Sciences shows that a risk model built from telomere-related senescence genes can independently predict ...
Massive phosphoproteome atlas maps kinase activity across 33 human cell lines
Researchers have built a phosphoproteome atlas covering more than 200,000 phosphorylation sites across 33 human cell lines, enabling faster phosphoproteomics ...
Misplaced Gap Junction Protein Drives Colorectal Cancer Spread—and Reveals a Drug Weakness
Researchers found that the gap junction protein Cx26 relocates to mitochondria in metastatic colorectal cancer, driving EMT and calcium signaling, ...
How a Brain Lymphoma Responds to Steroids on MRI May Predict Survival
A multicenter Austrian study finds that whether primary CNS lymphoma shrinks or grows on MRI after routine corticosteroid therapy strongly ...
Lysosome Gene Signature Offers New Prognostic Tool for Lung Cancer
Researchers have built a 13-gene lysosome-related signature that predicts survival, immune landscape, and drug responses in lung adenocarcinoma patients.
Fat-Fueled RNA Signals Predict Survival and Drug Response in Lung Cancer
A new integrative study identifies three lipid metabolism-related long non-coding RNAs that predict survival, immune landscape, and drug sensitivity in ...
RNA Chemical Tag ac4C Reveals Fibroblast Signal That Drives Colorectal Cancer Aggression
A comprehensive profiling study links the ac4C RNA modification to aggressive colorectal cancer and identifies CERCAM in cancer-associated fibroblasts as ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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