Givinostat blocks colorectal cancer growth by silencing ADAM12 through miR-1938
New research shows the HDAC inhibitor givinostat stalls colorectal cancer growth by upregulating miR-1938 to suppress ADAM12, with no systemic ...
Tag: drug mechanism
Famed brain cancer drug turns out to hit a metabolic enzyme, not its intended target
A comprehensive chemical biology study shows that the celebrated KDM4 inhibitor QC6352 and its clinical analog zavondemstat kill glioblastoma stem ...
Cancer Drug in Clinical Trials May Work Through an Entirely Different Target Than Assumed
A new study finds the experimental cancer drug zavondemstat and the research compound QC6352 act mainly by blocking the enzyme ...
Vitamin D Compound Tames Psoriasis by Switching Off a Hidden Inflammatory Gene
New research reveals that calcitriol, the active form of vitamin D, suppresses psoriatic inflammation and keratinocyte hyperproliferation by downregulating the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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