Review Assesses War Stress, Mental Health, and Nonvalvular Atrial Fibrillation Links in Ukraine
A narrative review examines how chronic war stress and mood disorders interact with nonvalvular atrial fibrillation in Ukraine, finding associative ...
Tag: drug-drug interactions
Antiemetic Drug Combination Linked to Elevated Diabetes Risk in Chemotherapy Patients
A large Japanese health claims analysis found that combining neurokinin-1 receptor antagonists with dexamethasone significantly increased the odds of new-onset ...
Graph-Tabular Model Improves Cold-Start Drug Interaction Prioritization in Disjoint Benchmark Testing
In a brief research report evaluating cold-start drug-drug interaction prioritization, the consistency-regularized RxDDI-ConsisGAT model achieved an AUROC of 0.8352 under ...
Blonanserin Combinations Generate 268 Adverse Event Signals in JADER Analysis
An analysis of the Japanese Adverse Drug Event Report database identified 268 adverse event signals for blonanserin combination therapies, with ...
Antifungal drug caspofungin lowers tacrolimus levels in kidney transplant recipients
A self-controlled observational study of kidney transplant recipients found that caspofungin co-administration was associated with significantly lower tacrolimus pre-dose concentrations ...
Regulators and Industry Face Complex Payload Disposition Challenges Across Fifteen Oncology ADCs
A comprehensive review of fifteen approved antibody-drug conjugates highlights diverse industry strategies and regulatory hurdles in evaluating the metabolic disposition, ...
Dual Pathway Framework Predicts Rare and Unseen Drug Interactions Using Semantic Descriptions
Researchers have developed a dual-pathway computational framework that combines molecular graphs, biological knowledge networks, and semantic descriptions to predict rare ...
Estimating metabolic pathway overlap in precision oncology: integrating pharmacogenetics and polypharmacy
Only a small fraction of the drugs recommended for gastrointestinal cancers are directly steered by known pharmacogenetic variants, yet the ...
Retrospective outpatient study links SSRI interaction flags to polypharmacy
A retrospective study of 3,476 outpatient prescriptions found potential SSRI drug interactions in 19.68% of regimens, with the number of ...
AI Model Reads Molecules Atom by Atom to Predict Dangerous Drug Combinations
A new multimodal transformer-CNN model called InfoMedex predicts 168 types of drug-drug interactions from molecular structure and uses atom-level attribution ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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