Tag: drug discovery

A 58-article special issue of Molecular Diversity shows how synthetic chemistry, protein degraders, natural products, and AI-driven screening are converging ...

Researchers have built a scalable transcriptomic screening platform that uses gene expression signatures and CRBN knockout cell models to systematically ...

A new review outlines how multi-omics, CRISPR functional genomics, artificial intelligence and host-directed immunotherapy can be integrated into a precision ...

Cryo-EM structures of the essential Candida albicans enzyme Chs1 reveal that a small-molecule inhibitor jams the chitin translocation channel, a ...

Researchers have identified a morpholine-substituted chalcone, TC12, that inhibits monoamine oxidase B at 11 nanomolar with over 3,600-fold selectivity and ...

A new study finds that extracts from the stem bark of the Himalayan tree Parrotiopsis jacquemontiana rival or exceed standard ...

A new review in Molecular Cancer provides a rigorous framework for how liquid–liquid phase separation drives cancer biology and evaluates ...

A new systematic review of 34 studies finds that Vietnamese coriander, Polygonum odoratum, shows broad antimicrobial, antioxidant, anti-inflammatory, anticancer and ...

Researchers at Peking University have developed SynCraft, a framework that uses large language models to predict precise atom-level edit sequences ...

A computational screen of more than 36,000 microbial natural products identified six potential GSK-3β inhibitors as candidate dual therapeutics for ...