High-altitude exposure linked to α-synuclein burden and mouse pathology
A multi-method study linked chronic high-altitude exposure to elevated α-synuclein levels and worse pathology in a mouse model, while human ...
Tag: dopaminergic neurons
AAV gene replacement restores Parkin pathway activity in preclinical tests
An AAV carrying functional human PRKN restored mitochondrial-pathway signaling in Parkin-deficient cells and patient fibroblasts, while rodent tests showed that ...
ABCA1 cholesterol trafficking implicated in Parkinson’s neurodegeneration in mice
Human postmortem tissue, cultured cells and mouse experiments implicated abnormal ABCA1-dependent cholesterol trafficking in Parkinson’s-related neurodegeneration.
Rehmannioside A protects dopaminergic neurons in rotenone Parkinson’s models
Rehmannioside A reduced oxidative stress and improved dopaminergic measures in rotenone-based Parkinson’s models, with experimental evidence indicating that PI3K/Akt signaling ...
Landmark Study Reveals How Cellular Recycling Falters in Parkinson’s Disease
A new study reveals that impaired proteasome function, driven by SUMOylation, may underlie the toxic accumulation of alpha-synuclein in Parkinson's ...
How Toxic Exposures Jam the Cell’s Nuclear Doorway in Parkinson’s Disease
New research shows that environmental neurotoxicants damage mitochondria in ways that break down the nuclear pore complex and disrupt nucleocytoplasmic ...
Single Gene Emerges as Hidden Link Between Oxygen Starvation and Neuron Death in Parkinson’s Disease
A multi-omics study identifies the mitochondrial pyruvate carrier gene MPC2 as a causal link between hypoxia, mitochondrial energy failure, and ...
Antioxidant Protein Thioredoxin-1 Reshapes Oligodendrocyte Lineage Cells in Parkinson’s Model
A new study shows that the antioxidant protein thioredoxin-1 regulates the expansion of oligodendrocyte lineage cells and the accumulation of ...
Scientists Map the Road to Better Stem Cell Brain Repair for Parkinson’s Disease
A new review in npj Parkinson's Disease examines the strategies needed to improve survival, differentiation and functional integration of stem ...
Ancient Herbal Polysaccharide Turned Self-Healing Brain Gel Shows Promise Against Parkinson’s Disease
An injectable self-healing hydrogel made from an oxidized polysaccharide of the traditional Chinese medicine herb Huangjing protects dopaminergic neurons in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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