Three sequencing methods tested on archival breast tumor DNA methylation
Researchers showed that whole-genome bisulfite sequencing, EM-seq, and the biomodal evoC kit are all feasible for DNA methylation profiling of ...
Tag: DNA Methylation
Epigenetic Split in AKAP12-LMOD1 Axis Shapes Colorectal Cancer Stroma and Epithelium
A Cell & Bioscience study links compartment-specific AKAP12 promoter methylation to opposing epithelial and stromal programs in colorectal cancer and ...
Cheek swabs and DNA methylation predict biological age and blood biomarkers
DNA methylation profiles from cheek swabs accurately predicted chronological age, phenotypic age, and many clinical biomarkers in 186 Japanese adults, ...
BRCA1/2 Mutation Carriers Show Fewer Active Ribosomal DNA Copies in Blood
Healthy women carrying pathogenic BRCA1 or BRCA2 variants have significantly fewer hypomethylated, presumably active ribosomal DNA copies in their blood ...
EBV-driven lymphoproliferative disorders show disrupted DNA methylation patterns
A new review links EBV-driven lymphoproliferative disorders to disrupted DNA methylation and outlines emerging epigenetic treatment strategies.
One Blood Test, Two Answers: Nanopore Sequencing Reads Genes and Methylation Together
Nanopore long-read sequencing that simultaneously reads genetic variants and DNA methylation resolved three difficult KMT2B-related dystonia diagnoses, confirming one uncertain ...
Omega-3 Fatty Acids Linked to Better Lung Health in Smokers Through Epigenetic Recovery
A large observational study of former and current smokers found that higher blood omega-3 fatty acids were associated with better ...
Mitochondrial DNA methylation signals in WGBS are mostly technical artifacts
A systematic analysis of hundreds of WGBS datasets finds that apparent mitochondrial DNA methylation is driven mainly by technical artifacts, ...
DNA Methylation Links Failing Fat Cell Formation to Obesity and Diabetes
A new review describes how aberrant DNA methylation and premature senescence of fat cell precursors drive adipose tissue dysfunction in ...
Tumour suppressor gene loss sparks childhood brain tumour in mice, revealing hidden driver
New mouse experiments show that losing the tumour suppressor Apc in pituitary stem cells is enough to cause adamantinomatous craniopharyngioma ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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