Tag: cryo-electron microscopy

A new review argues that ribosomes vary in composition and chemical state across biological contexts and proposes a four-step framework ...

Injecting tau filaments from Alzheimer's and corticobasal degeneration patients into wild-type mice induces endogenous tau pathologies with identical folded structures, ...

Cryo-electron microscopy captures RNA polymerase II remodeling cisplatin-induced DNA interstrand crosslinks into a novel conformation that blocks the active site, ...

A new review details how cryo-electron microscopy, AI modeling and time-resolved crystallography are decoding the multi-target synergy of traditional Chinese ...

Researchers have created a two-dimensional polymer network containing several distinct woven topologies at once, unlocking mechanical and separation properties impossible ...

The Blavatnik Regional Awards for Young Scientists have announced their 2026 Laureates and Finalists, honoring nine postdoctoral researchers across the ...

Researchers discovered a naturally nuclease-dead miniature CRISPR protein, engineered it into the hypercompact xCas12m, and showed that a single-AAV xCas12m–CRISPRoff ...

New cryo-EM structures of human ATR–ATRIP in multiple functional states reveal how ATP priming, TopBP1 binding and autophosphorylation activate the ...

Researchers show that small-molecule inhibitors shut down the Staphylococcus aureus NorA efflux pump by trapping the transporter in nonproductive conformational ...

Cryo-electron microscopy reveals that repositioned polyubiquitin chains outside the ordered core can remodel tau fibril ultrastructure and shift the protofilament ...