Induced Pluripotent Stem Cells Reshape Drug Discovery for Alzheimer’s, Diabetes and Cancer
A new review finds that induced pluripotent stem cells have transformed drug discovery for Alzheimer's disease, diabetes, arthritis and cancer ...
Tag: CRISPR
Yeast Genetics Map How Thousands of Variants Reshape the Protein Interactome
A large-scale study in budding yeast has mapped how roughly 12,000 natural genetic variants reshape the strength of protein–protein interactions ...
Scientists Use CRISPR to Strip Antibiotic Resistance From a Widely Used Probiotic
Researchers reprogrammed the native CRISPR-Cas system of a commercial probiotic bacterium to permanently disable its tetracycline resistance gene while preserving ...
Scientists engineer a miniature CRISPR protein to silence genes and curb hepatitis B
Researchers discovered a naturally nuclease-dead miniature CRISPR protein, engineered it into the hypercompact xCas12m, and showed that a single-AAV xCas12m–CRISPRoff ...
Scientists Ramp Up Licorice Sweetener Glycyrrhizin With Elicitation and CRISPR
A new review details how elicitation, genome editing and engineered yeast are being used to boost production of the medicinally ...
Collagen Switch Turns Fish Fins Into Limb-Like Structures
Deleting the fish-specific actinodin genes flips collagen fiber orientation in zebrafish fins from parallel to perpendicular, reshaping the appendage into ...
SOX9 Acts Early to Rewire Hippo–YAP/TAZ Signaling as Glioblastoma Cells Turn Stem-Like
New research shows that the transcription factor SOX9 primes Hippo–YAP/TAZ pathway rewiring during a narrow early window of stemness acquisition ...
Peptide Analog Boosts Non-Viral CRISPR Delivery in Primary Human Skin Cells
Researchers engineered a cell-penetrating peptide, PF14-K, that delivers CRISPR ribonucleoproteins and DNA repair templates into primary human skin cells with ...
Prime Editing Gets a Size Upgrade: Researchers Insert Large DNA Fragments with Precision
Researchers report a prime-editing strategy that integrates large DNA fragments into precise genomic sites through donor-directed annealing without double-strand breaks.
Cryo-EM Reveals How Cas12a Uses a DNA Guide to Hunt RNA Targets
A new cryo-EM structure of Acidaminococcus sp. Cas12a reveals how the enzyme uses a DNA guide and structural mimicry to ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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