Do Gene Perturbation Maps Travel Between Species and Cell Types? A New Stress Test Says Caution
A systematic reanalysis in Neuroinformatics finds that similarity structure from a mouse whole-brain perturbation atlas largely fails to transfer to ...
Tag: CRISPR screens
Cancer’s Hidden Proteome: Thousands of Dark Proteins Emerge as Drug Targets
A landmark Perspective in Nature Reviews Cancer argues that the cancer dark proteome — thousands of uncharacterized proteins from non-canonical ...
Famed brain cancer drug turns out to hit a metabolic enzyme, not its intended target
A comprehensive chemical biology study shows that the celebrated KDM4 inhibitor QC6352 and its clinical analog zavondemstat kill glioblastoma stem ...
CRISPR Screens Reveal DNMT3A’s Dual Role in Tumor Immune Evasion
In vivo CRISPR screens reveal that the epigenetic enzyme DNMT3A can both preserve and suppress tumor immune visibility, reshaping how ...
Scientists Block a Survival Switch That Lets Melanoma Cells Spread
Australian researchers have shown that blocking the BRN2 transcription factor reverses anoikis resistance in melanoma cells and sensitizes them to ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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