Gene brake ZMYND8 drives T-cell exhaustion and blocking it may strengthen immunotherapy
St. Jude scientists found that deleting the gene ZMYND8 relieves CD8-positive T-cell exhaustion and synergizes with immunotherapy to improve anti-tumor ...
Tag: CRISPR screening
From Dish to Living Brain: How Lab-Grown Human Microglia Are Rewriting Neuroimmune Research
A new review charts how stem cell-derived human microglia, brain organoids and chimeric mice are overcoming the genetic and environmental ...
CRISPR Screen Maps the Hidden Control Network of the Body’s Pollution-Sensing Receptor
A genome-scale CRISPR screen in human hepatocytes has revealed an extensive network of regulators governing the aryl hydrocarbon receptor, including ...
Machine Learning Map Reveals Hidden Paralog Vulnerabilities Across 1,005 Cancer Cell Lines
Researchers have built a machine learning framework that predicts context-specific synthetic lethal vulnerabilities between paralog gene pairs across 1,005 cancer ...
Feedback Loops, Not Pipelines: The Data-Centric Fix for Failing Immunotherapy Development
Researchers propose reframing drug development as an iterative, data-centric learning system in which single-cell readouts from human immunotherapy responses continuously ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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