New ESMF Method Sharpens Cell-Type Estimates from Bulk RNA Sequencing Data
A new deconvolution framework called ESMF uses single-cell reference data, negative binomial noise modeling and dual-validated marker selection to estimate ...
Tag: computational biology
Deep learning model predicts rice protein interactions from sequence data
A new deep learning framework called RCNNricePPI predicts rice protein-protein interactions from amino acid sequences, achieving an accuracy of 0.8996 ...
Machine Learning Pinpoints 12 Candidate Biomarkers for Mesothelioma
A computational study combined gene co-expression network analysis and machine learning to nominate twelve candidate biomarkers for malignant pleural mesothelioma, ...
New CSDE method corrects preprocessing bias in spatial transcriptomics
A new method called CSDE uses a small set of expert-validated cells to correct systematic preprocessing errors in spatial transcriptomics ...
AI tool maps candidate microRNA sites on circular RNAs
The circMAC model predicted candidate microRNA-binding regions across complete circular RNA isoforms while preserving sequence continuity at back-splice junctions.
AI Tool Designs DNA Sequences to Fold Genomes in Desired 3D Patterns
A new computational framework, Akita Semifreddo, combines a fast genome folding model with sequence optimization to design DNA with specified ...
Single-cell tumour phylogenetics
A Nature Reviews Cancer review surveys the statistical and computational methods that reconstruct tumour evolutionary histories from single-cell sequencing data ...
ReadsRatio method traces tissue origins of cell-free DNA across sequencing platforms
A new method called ReadsRatio estimates tissue contributions to circulating cell-free DNA from unmethylated read ratios in cell type-specific marker ...
Ten Rules for Keeping AI Honest in Computational Biology
A new PLOS Computational Biology perspective sets out ten practical rules defining where AI assistance in computational biology is legitimate ...
New metric speeds RNA alignment across arbitrary pseudoknots
SERNA and SERNAlign compare RNA secondary structures with arbitrary pseudoknots using integer sequences, achieving competitive clustering performance at lower computational ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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