When Lupus Masks the Lab: Why a Single Complement Test Can Mislead Angioedema Diagnosis
A Japanese family case report shows that profoundly low C1q, usually a hallmark of acquired angioedema, can instead reflect lupus-related ...
Tag: complement system
Complement biomarkers emerge as key guides in the new era of IgA nephropathy therapy
A new review maps how complement-related biomarkers in blood, urine and kidney tissue could guide diagnosis, prognosis and targeted therapy ...
Repurposed antimalarial drug wrapped in lactoferrin nanoparticles calms complement attack on motor nerves in ALS mice
A new preclinical study reports that atovaquone, an approved antiparasitic drug, was reformulated into lactoferrin-based nanomicelles that crossed into the ...
How the Immune System Matures, Ages, and Defies Time
A new review maps how human immunity develops from a deliberately tolerogenic newborn state through adult peak performance to the ...
Persistent C4d Deposits in ABO-Incompatible Kidney Grafts May Signal Quiet Danger, Study Finds
A Japanese study tracking sequential protocol biopsies finds that persistent C4d deposition in ABO-incompatible kidney grafts is not linked to ...
One Gene, Two Proteins: Why CFH Cancer Biomarker Studies May Be Measuring the Wrong Molecule
A new commentary in BMC Cancer warns that pan-cancer studies treating CFH as a single cancer biomarker have been measuring ...
Ancient Chinese Herb Powder Rides to the Rescue of Weaning-Stressed Goat Kids
A finely ground powder of the traditional Chinese herb Astragalus membranaceus significantly boosted the complement regulator C4bp and antibody IgM ...
Immune Gene Variants Hint at Why Some Children Develop Severe Hand, Foot, and Mouth Disease
A candidate-gene study of Chinese Han children finds nominal links between complement-related gene variants and severe Coxsackievirus A6 hand, foot, ...
Gene Silencing of Complement C3 Shields Nerve-Muscle Junctions in Myasthenia Gravis Rats
Silencing hepatic C3 with GalNAc-targeted siRNA nearly eliminated plasma complement, preserved acetylcholine receptors, and reduced muscle weakness in a rat ...
Scientists Turn Complement Footprints Into a Second Strike Against Drug-Resistant Cancer Cells
Researchers engineered an anti-C4d antibody that targets complement fragments left on tumor cells that survived antibody therapy, boosting complement-mediated killing ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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