Two-Drug Combo Supercharges Liver Cancer Therapy in Preclinical Study
A preclinical study reports that combining the kinase inhibitor regorafenib with the small-molecule PD-1/PD-L1 inhibitor BMS-1 synergistically suppresses the growth, ...
Tag: combination therapy
PI3K/AKT/mTOR Pathway Emerges as Central Target in Gastrointestinal Cancers
A comprehensive review finds that the PI3K/AKT/mTOR signaling axis drives progression and therapy resistance in gastrointestinal cancers, but clinical success ...
Old Antabuse Drug Turns Breast Cancer Resistance Against Itself
Researchers report that the repurposed alcoholism drug disulfiram exploits a collateral vulnerability in chemotherapy-resistant ER+ breast cancer cells, and that ...
Mushroom Compound Pachymic Acid Supercharges Lenvatinib Against Liver Cancer by Starving Tumors of Sugar
A new study shows that pachymic acid, a compound from the medicinal mushroom Poria cocos, synergizes with lenvatinib against hepatocellular ...
How Immunotherapy Is Rewriting the Rules of Liver Cancer Treatment
A sweeping review details how immune checkpoint inhibitors, combination regimens, CAR-T cells, vaccines, and oncolytic viruses are transforming treatment of ...
Two Decades of Data Reveal How Small Molecule Drugs Reshaped Lung Cancer Treatment
A two-decade bibliometric analysis of nearly 5,000 studies maps how small molecule drug research transformed lung cancer therapy, revealing China's ...
Triple Therapy Shows Edge in Lung Cancer Lacking Targetable Mutations
A new network meta-analysis of five trials involving 2,452 patients finds that triple therapy combining immunotherapy, antiangiogenic antibodies, and chemotherapy ...
Colistin Alone Matches Antibiotic Combos for Deadly Infections in Children, Study Finds
A 14-year Thai study of 218 children found that colistin-based combination therapy improved bacterial clearance but did not reduce mortality, ...
Old Dye Meets Nanoparticles in a Two-Pronged Attack on Glioblastoma
Researchers have combined IR780-paclitaxel albumin nanoparticles with acriflavine-releasing hydrogels to simultaneously block hypoxia-inducible factor 1 and heat shock protein 70, ...
Two Diabetes Drugs, One Powerful Punch: Real-World Data Reveal Semaglutide Plus SGLT2 Inhibitor Benefits
A post hoc analysis of the SCHOLAR study found that over 42 percent of Chinese adults starting semaglutide also took ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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