Adding Liver-Directed Therapy to Immunotherapy Doubles Survival in Advanced Liver Cancer
A two-center retrospective study found that adding TACE or HAIC to targeted-immunotherapy nearly doubled median overall survival in advanced hepatocellular ...
Tag: combination therapy
Blocking FGFR Signaling Supercharges Immunotherapy in Hard-to-Treat Colorectal Cancer
New research shows that inhibiting the FGFR signaling pathway reduces T cell exhaustion and repolarizes macrophages, significantly enhancing PD-1 blockade ...
Virtual Tumors Point to New Drug Combinations for Hard-to-Treat Lung Cancer Mutations
A new quantitative systems pharmacology model spanning all three classes of BRAF-mutant lung cancer predicts that MEK-ERK inhibitor combinations can ...
Immune Checkpoint Inhibitor Combos Ranked for Liver Cancer in Major Analysis
A network meta-analysis of eight randomized trials finds that immune checkpoint inhibitors combined with anti-VEGF therapy outperform other immunotherapy combinations ...
USP7: The Double-Edged Deubiquitinase That Tumors Cannot Live Without
A new review in Cancer Cell International maps how the deubiquitinase USP7 acts as both tumor promoter and suppressor depending ...
Virus-driven lymphoma cells rely on a mitochondrial enzyme duo to dodge cell death
New research reveals that the mitochondrial ubiquitin ligase MARCHF5 helps KSHV-transformed lymphoma cells survive by degrading NOXA, the natural antagonist ...
Machine Learning Predicts Antibacterial Drug Synergy Without Data Leakage
Researchers developed HALO, a machine-learning framework that predicts antibacterial drug synergy from multi-level bioactivity features while exposing how data leakage ...
Studying Stress One Factor at a Time Misleads Biology, Plant Scientist Argues
University of Missouri scientist Ron Mittler is urging biologists to study organisms under multiple simultaneous stressors, arguing that combined stresses ...
Macrolide Plus Nucleoside Combo Curbs SARS-CoV-2 and Shields Monkey Lungs
A Carrimycin and Azvudine combination showed additive antiviral effects, superior lung protection, and immune benefits in SARS-CoV-2-infected rhesus macaques.
Tigecycline Shows Promise Against Drug-Resistant Nontuberculous Mycobacteria, Review Finds
A new review of 28 studies reveals that tigecycline holds strong promise against rapidly growing nontuberculous mycobacteria like M. abscessus, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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