TWAS sign errors reach 33% in complex-trait analyses
A Nature Genetics analysis estimated that TWAS assigns the wrong effect direction to 23% of plasma-protein associations and 33% of ...
Tag: colocalization
Trans-ancestry meta-analysis identifies 116 gallstone disease risk loci
A trans-ancestry meta-analysis of 1,697,458 people identified 116 genetic risk loci for gallstone disease, including 59 previously unreported loci.
Blood Pressure Drugs May Hold Clues to Preventing Bipolar Disorder, Genetic Study Suggests
A Mendelian randomization study links diuretic use to lower bipolar disorder risk and identifies the ADO gene as a potential ...
Shared Genes, Opposing Effects: Hidden Genetic Link Between Heart Failure and Osteoporosis Revealed
A multi-omics study reveals that heart failure and osteoporosis share hundreds of genetic variants that often act in opposite directions, ...
Massive Genetic Study Reveals New Molecular Targets for Bronchiectasis Across Ancestries
A trans-ancestry genome-wide association study of over 16,000 bronchiectasis cases combined with multi-omics analyses has pinpointed SERPINA1 as the strongest ...
Massive single-nucleus atlas reveals how genetic risk for brain disease acts cell by cell
A single-nucleus atlas of 5.6 million brain cells from 1,384 donors maps cell-type-specific genetic regulation underlying Alzheimer's disease, schizophrenia and ...
Pig DNA Methylation Map Reveals Hidden Genetic Switches Behind Meat Traits
A massive multi-omics atlas of pig skeletal muscle shows how genetically regulated DNA methylation links sequence variation to gene expression ...
T-Cell Activation State Reshapes Asthma Genetics and Points to New Drug Targets
A large genetic analysis shows that asthma-linked gene regulation in CD4+ T cells changes with activation state, exposing dozens of ...
Genetic Study Pinpoints New Drug Targets for Common Mental Disorders
A combined Mendelian randomization and colocalization analysis of large genetic datasets has identified candidate drug targets for depression, anxiety, schizophrenia, ...
Protein Folding Genes Linked to Depression in Multi-Omics Genetic Study
A multi-omics Mendelian randomization study links protein folding-related genes PDIA3 and FNIP2 to genetically supported risk of major depressive disorder.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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