Immune checkpoint protein B7-H6 emerges as a driver and vulnerability in metastatic kidney cancer
B7-H6 expression on tumor cells and tumor-infiltrating leukocytes is linked to metastasis, lymph node spread and reduced overall survival in ...
Tag: clear cell renal cell carcinoma
TTC39B emerges as a pan-cancer prognostic marker suppressing renal cancer cell growth
A pan-cancer analysis links TTC39B expression to prognosis and tumor immunity across 33 cancer types, with experiments showing the gene ...
Immune Cell Genes Track Ferroptosis Signals in Kidney Cancer
A multi-cohort study finds that five genes upregulated in clear cell renal cell carcinoma mark the immune microenvironment rather than ...
Long-Read RNA Sequencing Reveals Full-Length HERV Transcripts and Novel ERVE-4 Isoforms in Clear Cell Renal Cell Carcinoma
A new long-read RNA sequencing workflow uncovered hundreds of HERV loci missed by short-read methods and revealed novel ERVE-4 isoforms ...
Tissue marker KIM-1 flags early kidney cancer recurrence missed by adjuvant criteria
In a two-centre exploratory study of 117 clear-cell renal cell carcinoma patients, 43.5% of recurrences within 24 months occurred among ...
Younger and older clear cell kidney cancers follow distinct metabolic programs
A retrospective study of 1,979 patients finds that clear cell renal cell carcinoma diagnosed at age 45 or younger shows ...
DNA Methylation of Two Long Non-Coding RNA Loci Tracks Metastatic Disease in Kidney Cancer
DNA methylation at the LINC01354 and LINC01510 long non-coding RNA loci rises with tumor stage, grade and metastatic spread in ...
STAM protein suppresses kidney cancer through a dual EGFR and AKT mechanism
New preclinical research shows the STAM protein suppresses clear cell renal cell carcinoma by inactivating EGFR and degrading AKT, inducing ...
RNF152 Tags PD-L1 for Destruction and Curbs Immune Evasion in Kidney Cancer
A study in Medical Oncology reports that the E3 ubiquitin ligase RNF152 is low in clear cell renal cell carcinoma, ...
Lactylation gene signature predicts outcomes in clear cell renal cell carcinoma
A machine-learning 15-gene lactylation signature predicts prognosis and drug response in clear cell renal cell carcinoma, with CCNA2 identified as ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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