Chaperonin Protein CCT2 Emerges as Key Driver of Aggressive Head and Neck Cancer and Cisplatin Resistance
New research shows that the chaperonin subunit CCT2 stabilizes the oncoprotein c-Myc to drive head and neck squamous cell carcinoma ...
Tag: cisplatin resistance
Scientists Uncover How Oral Cancer Cells Outsmart Cisplatin by Blocking Ferroptosis
New research reveals that the secreted protein DKK1 helps oral squamous cell carcinoma resist cisplatin by keeping the SLC3A2 cystine ...
Low Oxygen Inside Tumors Fuels Cervical Cancer Growth and Cisplatin Resistance, Study Finds
Researchers at Chongqing Medical University report that hypoxia silences the tumor suppressor CCNDBP1 in cervical cancer, activating a USP11–Nrf2 antioxidant ...
Zinc Complexes Emerge as Safer Rivals to Platinum Cancer Drugs, Landmark Review Finds
A systematic review of 66 zinc(II) Schiff base complexes shows that octahedral geometry and red-shifted imine infrared signatures predict potent, ...
Scientists Uncover a Fat-Metabolism Switch That Fuels Esophageal Cancer and Blunts Chemotherapy
A new study shows that the transcription factor ELF4 activates the enzyme UGT8, reshaping sphingolipid metabolism to drive esophageal squamous ...
Single Gene Mutation Reveals Why Throat Cancers Come Back After Cisplatin Success
A new study shows that mutations emerging in the ENPP1 gene during treatment drive cisplatin resistance and recurrence in hypopharyngeal ...
Cancer Gene Duo Reveals Why Head and Neck Tumors Shrug Off Cisplatin
New research links the SERPINE1–CA9 gene axis to both aggressive growth and cisplatin resistance in head and neck squamous cell ...
Sono-Activated Platinum-Manganese Nanodendrites Trigger Ferroptosis and PANoptosis to Defeat Drug-Resistant Breast Cancer
Engineered platinum-manganese nanodendrites activated by ultrasound concurrently trigger ferroptosis and PANoptosis, overcoming cisplatin resistance in breast cancer models.
Tβ4–17 Boosts Ovarian Cancer Chemo-Sensitivity via NF-κB
In a groundbreaking advance that could revolutionize the treatment landscape for ovarian cancer, researchers have unveiled compelling evidence that the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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